Ventilation pattern at rest and respiratory response to hypercapnic stimulation after lung transplantation

We aimed to assess breathing pattern at rest by studying occlusion pressure after the first 100 miliseconds (P0.1) and ventilatory response to hypercapnia after lung transplantation. Seven transplanted patients were compared with a control group of 7 healthy subjects. The breathing pattern at rest a...

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Bibliographic Details
Published in:Archivos de bronconeumología 1994-11, Vol.30 (9), p.440-444
Main Authors: Morales, P, Cordero, P, Borro, J M, Macián, V, Marco, V
Format: Article
Language:Spanish
Subjects:
Adult
Female
Humans
Hypercapnia - physiopathology
Lung Transplantation
Male
Respiration
Respiratory Function Tests
Rest
Space life sciences
Tidal Volume
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Summary:We aimed to assess breathing pattern at rest by studying occlusion pressure after the first 100 miliseconds (P0.1) and ventilatory response to hypercapnia after lung transplantation. Seven transplanted patients were compared with a control group of 7 healthy subjects. The breathing pattern at rest after transplantation included a significant increase in minute volume (VE) at the expense of an increase in tidal volume (VT) and above all of mean inspiratory flow (VT/Ti). There were no significant differences in ventilatory response to hypercapnia between the 2 groups, although the response curves of both VE and VT to CO2 tended to slope downward. These results can be explained by the mechanics of ventilation in some subjects studied and by the effect of pulmonary denervation on ventilatory control.
ISSN:0300-2896