The distribution of blood flow to the whole skeleton in dogs, rabbits and rats measured with microspheres

The distribution of blood flow to the skeleton was studied by injecting radioactive microspheres into the hearts of anaesthetised adult animals and measuring activity in individual bones and groups of bones. The mean proportion of the cardiac output delivered to the whole skeleton was 7.5% in dogs,...

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Bibliographic Details
Published in:Clinical physics and physiological measurement 1986-05, Vol.7 (2), p.117-123
Main Authors: Tothill, P, MacPherson, J N
Format: Article
Language:English
Subjects:
Animals
Bone and Bones - blood supply
Cobalt Radioisotopes
Dogs
Microspheres
Rabbits
Radioisotopes
Rats
Regional Blood Flow
Species Specificity
Strontium Radioisotopes
Tin
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Summary:The distribution of blood flow to the skeleton was studied by injecting radioactive microspheres into the hearts of anaesthetised adult animals and measuring activity in individual bones and groups of bones. The mean proportion of the cardiac output delivered to the whole skeleton was 7.5% in dogs, 4.2% in rabbits and 4.5% in rats. The results throw doubt on the value for rats of 27% published by Brookes. There was a wide range of flow per unit mass of bone in different parts of the skeleton, demonstrating the inaccuracy of predicting total skeletal flow from measurements on a single bone. The relative distribution to different parts of the skeleton was similar in the three species, but there were quantitative differences.
ISSN:0143-0815
DOI:10.1088/0143-0815/7/2/002