Predicting Mycobacterium avium Complex Bacteremia in Patients Infected with Human Immunodeficiency Virus: A Prospectively Validated Model

In cases of advanced infection with human immunodeficiency virus, mycobacterial blood cultures are frequently used to diagnose disseminated infection with the Mycobacterium avium complex (MAC). However, no prospectively validated guidelines exist for the use of such cultures. In this study, a two-pa...

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Bibliographic Details
Published in:Clinical infectious diseases 1994-10, Vol.19 (4), p.668-674
Main Authors: Chin, Daniel P., Reingold, Arthur L., Horsburgh, C. Robert, Yajko, David M., Hadley, W. Keith, Elkin, Eric P., Stone, Elizabeth N., Simon, Ellen M., Gonzalez, Patricia C., Ostroff, Stephen M., Jacobson, Mark A., Hopewell, Philip C.
Format: Article
Language:English
Subjects:
Adult
AIDS-Related Opportunistic Infections - blood
AIDS-Related Opportunistic Infections - diagnosis
AIDS-Related Opportunistic Infections - physiopathology
AIDS/HIV
Bacteremia
Bacteremia - blood
Bacteremia - complications
Bacteremia - diagnosis
Bacteremia - physiopathology
Bacteriological Techniques
Blood
CD4 Lymphocyte Count
Clinical Infectious Disease Articles
Cultured cells
Decision Support Techniques
Female
Fever
Hematocrit
HIV
HIV Infections - complications
human immunodeficiency virus
Humans
Infections
Male
Middle Aged
Modeling
Mycobacterium avium
Mycobacterium avium complex
Mycobacterium avium Complex - isolation & purification
Mycobacterium avium-intracellulare Infection - blood
Mycobacterium avium-intracellulare Infection - complications
Mycobacterium avium-intracellulare Infection - diagnosis
Mycobacterium avium-intracellulare Infection - physiopathology
Predictive Value of Tests
Symptoms
Citations: Items that cite this one
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Summary:In cases of advanced infection with human immunodeficiency virus, mycobacterial blood cultures are frequently used to diagnose disseminated infection with the Mycobacterium avium complex (MAC). However, no prospectively validated guidelines exist for the use of such cultures. In this study, a two-part model for predicting MAC bacteremia was developed and then validated prospectively. First, a CD4+ cell count of ⩽50/µL was used to predict bacteremia. then, among patients with ⩽50 CD4+ cellS/µL, the documentation of fever on more than 30 days during the preceding 3 months, a hematocrit of
ISSN:1058-4838
1537-6591
DOI:10.1093/clinids/19.4.668