Senescence-related changes in gene expression in muscle: similarities and differences between mice and men

1 Departments of Medicine 2 Pharmacology and Physiology 3 Neurology 4 Center for Aging and Developmental Biology, University of Rochester, Rochester, New York 14642 A microarray study of the effect of senescence in mice on gene expression in muscle has been published recently. The present analysis w...

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Bibliographic Details
Published in:Physiological genomics 2001-03, Vol.5 (2), p.67-73
Main Authors: WELLE, STEPHEN, BROOKS, ANDREW, THORNTON, CHARLES A
Format: Article
Language:English
Subjects:
Adult
Aged
Aging - genetics
Aging - physiology
Animals
Conserved Sequence - genetics
Databases as Topic
DNA Probes
Energy Intake
Gene Expression Profiling
Gene Expression Regulation, Developmental
Humans
Internet
Mice
Mice, Inbred C57BL
Muscle, Skeletal - metabolism
Muscle, Skeletal - physiology
Oligonucleotide Array Sequence Analysis
Physical Fitness
RNA, Messenger - genetics
RNA, Messenger - metabolism
Sequence Homology, Nucleic Acid
Stress, Physiological - genetics
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Summary:1 Departments of Medicine 2 Pharmacology and Physiology 3 Neurology 4 Center for Aging and Developmental Biology, University of Rochester, Rochester, New York 14642 A microarray study of the effect of senescence in mice on gene expression in muscle has been published recently. The present analysis was done to evaluate the extent to which the age-related differences in gene expression in murine muscle are also evident in human muscle. RNA extracted from muscle of young (21–24 yr) and old men (66–77 yr) was studied both by serial analysis of gene expression (SAGE) and by oligonucleotide microarrays. SAGE tags were detected for 61 genes homologous to genes reported to be differentially expressed in young and old murine muscle. The microarray had probe sets for 70 homologous genes. For 17 genes, there was evidence for a similar age-related change in expression in muscles of mice and men. For 32 other genes, there was evidence that the effect of age on the level of expression is not the same in mice and men. There was no evidence that older human muscle has increased expression of the stress response genes that are increased in old murine muscle. SAGE; serial analysis of gene expression; microarray; aging
ISSN:1094-8341
1531-2267
DOI:10.1152/physiolgenomics.2001.5.2.67