Relation of Two Different Subtypes of Croup Before Age Three to Wheezing, Atopy, and Pulmonary Function During Childhood: A Prospective Study

Some retrospective evidence suggests that children with a history of croup may be at increased risk of subsequently developing asthma, atopy, and diminished pulmonary function. The objective of this study was to determine the long-term outcome of croup (as diagnosed by a physician) in early life. Lo...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2001-03, Vol.107 (3), p.512-518
Main Authors: Castro-Rodriguez, Jose A, Holberg, Catharine J, Morgan, Wayne J, Wright, Anne L, Halonen, Marilyn, Taussig, Lynn M, Martinez, Fernando D
Format: Article
Language:English
Subjects:
Asthma
Asthma - epidemiology
Asthma in children
Biological and medical sciences
Child
Child development
Child, Preschool
Childhood asthma
Children & youth
Complications and side effects
Croup
Croup - classification
Croup - complications
Croup - physiopathology
Humans
Immunoglobulin E - blood
Infant
Infant, Newborn
Logistic Models
Longitudinal Studies
Lungs
Medical sciences
Pediatrics
Pneumology
Respiratory Function Tests
Respiratory Hypersensitivity - epidemiology
Respiratory Sounds - etiology
Respiratory system : syndromes and miscellaneous diseases
Respiratory Tract Diseases - complications
Respiratory Tract Diseases - epidemiology
Rhinitis, Allergic, Seasonal - epidemiology
Risk Factors
Skin Tests
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Summary:Some retrospective evidence suggests that children with a history of croup may be at increased risk of subsequently developing asthma, atopy, and diminished pulmonary function. The objective of this study was to determine the long-term outcome of croup (as diagnosed by a physician) in early life. Lower respiratory illnesses (LRIs) in the first 3 years of life were assessed in 884 children who were enrolled in a large longitudinal study of airway diseases at birth. Pulmonary function tests, markers of atopy, and wheezing episodes were studied at different ages between birth and 13 years. Ten percent of children had croup with wheeze (Croup/Wheeze), 5% had croup without wheeze (Croup/No Wheeze), 36% had another LRI (Other LRI), and 48% had no LRI. Respiratory syncytial virus was more frequently isolated in children with Croup/Wheeze and Other LRI than in those with Croup/No Wheeze. There was no association between croup in early life and markers of atopy measured during the school years. Only children with Croup/Wheeze and with Other LRI had a significant risk of subsequent persistent wheeze later in life. Significantly lower levels of indices of intrapulmonary airway function were observed at ages
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.107.3.512