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Relation of Two Different Subtypes of Croup Before Age Three to Wheezing, Atopy, and Pulmonary Function During Childhood: A Prospective Study
Some retrospective evidence suggests that children with a history of croup may be at increased risk of subsequently developing asthma, atopy, and diminished pulmonary function. The objective of this study was to determine the long-term outcome of croup (as diagnosed by a physician) in early life. Lo...
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| Published in: | Pediatrics (Evanston) 2001-03, Vol.107 (3), p.512-518 |
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| container_title | Pediatrics (Evanston) |
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| creator | Castro-Rodriguez, Jose A Holberg, Catharine J Morgan, Wayne J Wright, Anne L Halonen, Marilyn Taussig, Lynn M Martinez, Fernando D |
| description | Some retrospective evidence suggests that children with a history of croup may be at increased risk of subsequently developing asthma, atopy, and diminished pulmonary function. The objective of this study was to determine the long-term outcome of croup (as diagnosed by a physician) in early life.
Lower respiratory illnesses (LRIs) in the first 3 years of life were assessed in 884 children who were enrolled in a large longitudinal study of airway diseases at birth. Pulmonary function tests, markers of atopy, and wheezing episodes were studied at different ages between birth and 13 years.
Ten percent of children had croup with wheeze (Croup/Wheeze), 5% had croup without wheeze (Croup/No Wheeze), 36% had another LRI (Other LRI), and 48% had no LRI. Respiratory syncytial virus was more frequently isolated in children with Croup/Wheeze and Other LRI than in those with Croup/No Wheeze. There was no association between croup in early life and markers of atopy measured during the school years. Only children with Croup/Wheeze and with Other LRI had a significant risk of subsequent persistent wheeze later in life. Significantly lower levels of indices of intrapulmonary airway function were observed at ages |
| doi_str_mv | 10.1542/peds.107.3.512 |
| format | article |
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Lower respiratory illnesses (LRIs) in the first 3 years of life were assessed in 884 children who were enrolled in a large longitudinal study of airway diseases at birth. Pulmonary function tests, markers of atopy, and wheezing episodes were studied at different ages between birth and 13 years.
Ten percent of children had croup with wheeze (Croup/Wheeze), 5% had croup without wheeze (Croup/No Wheeze), 36% had another LRI (Other LRI), and 48% had no LRI. Respiratory syncytial virus was more frequently isolated in children with Croup/Wheeze and Other LRI than in those with Croup/No Wheeze. There was no association between croup in early life and markers of atopy measured during the school years. Only children with Croup/Wheeze and with Other LRI had a significant risk of subsequent persistent wheeze later in life. Significantly lower levels of indices of intrapulmonary airway function were observed at ages <1 (before any LRI), 6, and 11 years in children with Croup/Wheeze and Other LRI compared with children with No LRI. Conversely, inspiratory resistance before any LRI episode was significantly higher in infants who later developed Croup/No Wheeze than in the other 3 groups.
We distinguish 2 manifestations of croup with and without wheezing. Children who present with croup may or may not be at increased risk of subsequent recurrent lower airway obstruction, depending on the initial lower airway involvement, and preillness and postillness abnormalities in lung function associated with this condition.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.107.3.512</identifier><identifier>PMID: 11230591</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>Elk Grove Village, IL: Am Acad Pediatrics</publisher><subject>Asthma ; Asthma - epidemiology ; Asthma in children ; Biological and medical sciences ; Child ; Child development ; Child, Preschool ; Childhood asthma ; Children & youth ; Complications and side effects ; Croup ; Croup - classification ; Croup - complications ; Croup - physiopathology ; Humans ; Immunoglobulin E - blood ; Infant ; Infant, Newborn ; Logistic Models ; Longitudinal Studies ; Lungs ; Medical sciences ; Pediatrics ; Pneumology ; Respiratory Function Tests ; Respiratory Hypersensitivity - epidemiology ; Respiratory Sounds - etiology ; Respiratory system : syndromes and miscellaneous diseases ; Respiratory Tract Diseases - complications ; Respiratory Tract Diseases - epidemiology ; Rhinitis, Allergic, Seasonal - epidemiology ; Risk Factors ; Skin Tests</subject><ispartof>Pediatrics (Evanston), 2001-03, Vol.107 (3), p.512-518</ispartof><rights>2001 INIST-CNRS</rights><rights>COPYRIGHT 2001 American Academy of Pediatrics</rights><rights>Copyright American Academy of Pediatrics Mar 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c596t-7a8e68c104185ae600b8db8165b5a457d51c985df1a10ddbb239a069f2d7145d3</citedby><cites>FETCH-LOGICAL-c596t-7a8e68c104185ae600b8db8165b5a457d51c985df1a10ddbb239a069f2d7145d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=910003$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11230591$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Castro-Rodriguez, Jose A</creatorcontrib><creatorcontrib>Holberg, Catharine J</creatorcontrib><creatorcontrib>Morgan, Wayne J</creatorcontrib><creatorcontrib>Wright, Anne L</creatorcontrib><creatorcontrib>Halonen, Marilyn</creatorcontrib><creatorcontrib>Taussig, Lynn M</creatorcontrib><creatorcontrib>Martinez, Fernando D</creatorcontrib><title>Relation of Two Different Subtypes of Croup Before Age Three to Wheezing, Atopy, and Pulmonary Function During Childhood: A Prospective Study</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>Some retrospective evidence suggests that children with a history of croup may be at increased risk of subsequently developing asthma, atopy, and diminished pulmonary function. The objective of this study was to determine the long-term outcome of croup (as diagnosed by a physician) in early life.
Lower respiratory illnesses (LRIs) in the first 3 years of life were assessed in 884 children who were enrolled in a large longitudinal study of airway diseases at birth. Pulmonary function tests, markers of atopy, and wheezing episodes were studied at different ages between birth and 13 years.
Ten percent of children had croup with wheeze (Croup/Wheeze), 5% had croup without wheeze (Croup/No Wheeze), 36% had another LRI (Other LRI), and 48% had no LRI. Respiratory syncytial virus was more frequently isolated in children with Croup/Wheeze and Other LRI than in those with Croup/No Wheeze. There was no association between croup in early life and markers of atopy measured during the school years. Only children with Croup/Wheeze and with Other LRI had a significant risk of subsequent persistent wheeze later in life. Significantly lower levels of indices of intrapulmonary airway function were observed at ages <1 (before any LRI), 6, and 11 years in children with Croup/Wheeze and Other LRI compared with children with No LRI. Conversely, inspiratory resistance before any LRI episode was significantly higher in infants who later developed Croup/No Wheeze than in the other 3 groups.
We distinguish 2 manifestations of croup with and without wheezing. Children who present with croup may or may not be at increased risk of subsequent recurrent lower airway obstruction, depending on the initial lower airway involvement, and preillness and postillness abnormalities in lung function associated with this condition.</description><subject>Asthma</subject><subject>Asthma - epidemiology</subject><subject>Asthma in children</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child development</subject><subject>Child, Preschool</subject><subject>Childhood asthma</subject><subject>Children & youth</subject><subject>Complications and side effects</subject><subject>Croup</subject><subject>Croup - classification</subject><subject>Croup - complications</subject><subject>Croup - physiopathology</subject><subject>Humans</subject><subject>Immunoglobulin E - blood</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Logistic Models</subject><subject>Longitudinal Studies</subject><subject>Lungs</subject><subject>Medical sciences</subject><subject>Pediatrics</subject><subject>Pneumology</subject><subject>Respiratory Function Tests</subject><subject>Respiratory Hypersensitivity - epidemiology</subject><subject>Respiratory Sounds - etiology</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Respiratory Tract Diseases - complications</subject><subject>Respiratory Tract Diseases - epidemiology</subject><subject>Rhinitis, Allergic, Seasonal - epidemiology</subject><subject>Risk Factors</subject><subject>Skin Tests</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNpt0kFv0zAYBuAIgVgZXDkiCyTEoSl2EscJt9KxgVRpEyviaDn2l8RTGme2wyj_gf-MSyu2osqH2PFjf4n9RtFLgmeEZsn7AZSbEcxm6YyS5FE0Ibgs4ixh9HE0wTglcYYxPYmeOXeDMc4oS55GJ4QkKaYlmUS_v0InvDY9MjVa3Rl0pusaLPQeXY-V3wzgtjMLa8YBfYTaWEDzBtCqtQDIG_S9Bfil-2aK5t4MmykSvUJXY7c2vbAbdD728u_2Z6MNCi1a3anWGPUBzdGVNW6AMP8D0LUf1eZ59KQWnYMX--dp9O3802rxOV5eXnxZzJexpGXuYyYKyAtJcEYKKiDHuCpUVZCcVlSEX1SUyLKgqiaCYKWqKklLgfOyThQjGVXpafR2t-9gze0IzvO1dhK6TvRgRsdZXrKS5XmAr_-DN2a0ffg2niRFSlKapAFNd6gRHXDd18ZbIRvowYrO9FDr8HrOSMFSlm95fISHpmCt5TH_7sAH4uGnb8ToHC8ulgd0eoxK03XQAA9nuLg84LMdl-EinIWaD1avw7Vxgvk2XnwbrzBgPOUhXmHBq_1xjNUa1D3f5ymAN3sgnBRdbUUvtfvnShIy-KBuq5v2TlvY1tHCWy3dg-593T_T8OYP</recordid><startdate>20010301</startdate><enddate>20010301</enddate><creator>Castro-Rodriguez, Jose A</creator><creator>Holberg, Catharine J</creator><creator>Morgan, Wayne J</creator><creator>Wright, Anne L</creator><creator>Halonen, Marilyn</creator><creator>Taussig, Lynn M</creator><creator>Martinez, Fernando D</creator><general>Am Acad Pediatrics</general><general>American Academy of Pediatrics</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20010301</creationdate><title>Relation of Two Different Subtypes of Croup Before Age Three to Wheezing, Atopy, and Pulmonary Function During Childhood: A Prospective Study</title><author>Castro-Rodriguez, Jose A ; Holberg, Catharine J ; Morgan, Wayne J ; Wright, Anne L ; Halonen, Marilyn ; Taussig, Lynn M ; Martinez, Fernando D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c596t-7a8e68c104185ae600b8db8165b5a457d51c985df1a10ddbb239a069f2d7145d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Asthma</topic><topic>Asthma - epidemiology</topic><topic>Asthma in children</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child development</topic><topic>Child, Preschool</topic><topic>Childhood asthma</topic><topic>Children & youth</topic><topic>Complications and side effects</topic><topic>Croup</topic><topic>Croup - classification</topic><topic>Croup - complications</topic><topic>Croup - physiopathology</topic><topic>Humans</topic><topic>Immunoglobulin E - blood</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Logistic Models</topic><topic>Longitudinal Studies</topic><topic>Lungs</topic><topic>Medical sciences</topic><topic>Pediatrics</topic><topic>Pneumology</topic><topic>Respiratory Function Tests</topic><topic>Respiratory Hypersensitivity - epidemiology</topic><topic>Respiratory Sounds - etiology</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Respiratory Tract Diseases - complications</topic><topic>Respiratory Tract Diseases - epidemiology</topic><topic>Rhinitis, Allergic, Seasonal - epidemiology</topic><topic>Risk Factors</topic><topic>Skin Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Castro-Rodriguez, Jose A</creatorcontrib><creatorcontrib>Holberg, Catharine J</creatorcontrib><creatorcontrib>Morgan, Wayne J</creatorcontrib><creatorcontrib>Wright, Anne L</creatorcontrib><creatorcontrib>Halonen, Marilyn</creatorcontrib><creatorcontrib>Taussig, Lynn M</creatorcontrib><creatorcontrib>Martinez, Fernando D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Castro-Rodriguez, Jose A</au><au>Holberg, Catharine J</au><au>Morgan, Wayne J</au><au>Wright, Anne L</au><au>Halonen, Marilyn</au><au>Taussig, Lynn M</au><au>Martinez, Fernando D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relation of Two Different Subtypes of Croup Before Age Three to Wheezing, Atopy, and Pulmonary Function During Childhood: A Prospective Study</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2001-03-01</date><risdate>2001</risdate><volume>107</volume><issue>3</issue><spage>512</spage><epage>518</epage><pages>512-518</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>Some retrospective evidence suggests that children with a history of croup may be at increased risk of subsequently developing asthma, atopy, and diminished pulmonary function. The objective of this study was to determine the long-term outcome of croup (as diagnosed by a physician) in early life.
Lower respiratory illnesses (LRIs) in the first 3 years of life were assessed in 884 children who were enrolled in a large longitudinal study of airway diseases at birth. Pulmonary function tests, markers of atopy, and wheezing episodes were studied at different ages between birth and 13 years.
Ten percent of children had croup with wheeze (Croup/Wheeze), 5% had croup without wheeze (Croup/No Wheeze), 36% had another LRI (Other LRI), and 48% had no LRI. Respiratory syncytial virus was more frequently isolated in children with Croup/Wheeze and Other LRI than in those with Croup/No Wheeze. There was no association between croup in early life and markers of atopy measured during the school years. Only children with Croup/Wheeze and with Other LRI had a significant risk of subsequent persistent wheeze later in life. Significantly lower levels of indices of intrapulmonary airway function were observed at ages <1 (before any LRI), 6, and 11 years in children with Croup/Wheeze and Other LRI compared with children with No LRI. Conversely, inspiratory resistance before any LRI episode was significantly higher in infants who later developed Croup/No Wheeze than in the other 3 groups.
We distinguish 2 manifestations of croup with and without wheezing. Children who present with croup may or may not be at increased risk of subsequent recurrent lower airway obstruction, depending on the initial lower airway involvement, and preillness and postillness abnormalities in lung function associated with this condition.</abstract><cop>Elk Grove Village, IL</cop><pub>Am Acad Pediatrics</pub><pmid>11230591</pmid><doi>10.1542/peds.107.3.512</doi><tpages>7</tpages></addata></record> |
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| ispartof | Pediatrics (Evanston), 2001-03, Vol.107 (3), p.512-518 |
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| source | EZB-FREE-00999 freely available EZB journals |
| subjects | Asthma Asthma - epidemiology Asthma in children Biological and medical sciences Child Child development Child, Preschool Childhood asthma Children & youth Complications and side effects Croup Croup - classification Croup - complications Croup - physiopathology Humans Immunoglobulin E - blood Infant Infant, Newborn Logistic Models Longitudinal Studies Lungs Medical sciences Pediatrics Pneumology Respiratory Function Tests Respiratory Hypersensitivity - epidemiology Respiratory Sounds - etiology Respiratory system : syndromes and miscellaneous diseases Respiratory Tract Diseases - complications Respiratory Tract Diseases - epidemiology Rhinitis, Allergic, Seasonal - epidemiology Risk Factors Skin Tests |
| title | Relation of Two Different Subtypes of Croup Before Age Three to Wheezing, Atopy, and Pulmonary Function During Childhood: A Prospective Study |
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