Alpha-adrenergic agonists inhibit the dipsogenic effect of angiotensin II by their stimulation of atrial natriuretic peptide release

Angiotensin II (ANG-II) and atrial natriuretic peptide (ANP) have opposing actions on water and salt intake and excretion. Within the brain ANP inhibits drinking induced by ANG-II and blocks dehydration-induced drinking known to be caused by release of ANG-II. Alpha-adrenergic agonists are known to...

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Bibliographic Details
Published in:Brain research 2001-03, Vol.895 (1), p.80-88
Main Authors: Bastos, Rosemary, Favaretto, Ana Lúcia Vianna, Gutkowska, Jolanta, McCann, Samuel M, Antunes-Rodrigues, José
Format: Article
Language:English
Subjects:
Adrenergic alpha-Agonists - pharmacology
Angiotensin II - antagonists & inhibitors
Angiotensin II - metabolism
Angiotensin II - pharmacology
Animals
Atrial Natriuretic Factor - blood
Atrial Natriuretic Factor - drug effects
AV3V
Biological and medical sciences
Clonidine (α 2-adrenergic agonist)
Clonidine - pharmacology
Dose-Response Relationship, Drug
Drinking - drug effects
Drinking - physiology
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Hypothalamus - drug effects
Hypothalamus - metabolism
Injections, Intraventricular
Male
median eminence
Neurons - drug effects
Neurons - metabolism
Phenylephrine (α 1-adrenergic receptor agonist)
Phenylephrine - pharmacology
Plasma ANP
Rats
Rats, Wistar
Sodium Chloride - pharmacology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Water intake
Water-Electrolyte Balance - drug effects
Water-Electrolyte Balance - physiology
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Summary:Angiotensin II (ANG-II) and atrial natriuretic peptide (ANP) have opposing actions on water and salt intake and excretion. Within the brain ANP inhibits drinking induced by ANG-II and blocks dehydration-induced drinking known to be caused by release of ANG-II. Alpha-adrenergic agonists are known to release ANP and antagonize ANG II-induced drinking. We examined the hypothesis that α agonists block ANG-II-induced drinking by stimulating the release of ANP from ANP-secreting neurons (ANPergic neurons) within the brain that inhibit the effector neurons stimulated by ANG-II to induce drinking. Injection of ANG-II (12.5 ng) into the anteroventral region of the third ventricle (AV3V) at the effective dose to increase water intake increased plasma ANP concentrations ( P
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(01)02033-9