Interpretation of antibacterial susceptibility reports: In vitro versus clinical break-points

Currently, antibacterial activity is measured primarily via in vitro laboratory tests. Clinicians rely heavily upon the reported susceptibility gained via in vitro laboratory tests when choosing an antibacterial agent. An evolving concept is to utilise pharmacodynamic and pharmacokinetic drug proper...

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Bibliographic Details
Published in:Drugs (New York, N.Y.) N.Y.), 2001, Vol.61 (2), p.163-166
Main Authors: AMSDEN, Guy W, DURAN, Janelle M
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacokinetics
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteria - drug effects
Biological and medical sciences
Colony Count, Microbial
Drug Resistance, Microbial
Humans
Medical sciences
Microbial Sensitivity Tests - methods
Pharmacology. Drug treatments
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Summary:Currently, antibacterial activity is measured primarily via in vitro laboratory tests. Clinicians rely heavily upon the reported susceptibility gained via in vitro laboratory tests when choosing an antibacterial agent. An evolving concept is to utilise pharmacodynamic and pharmacokinetic drug properties in addition to in vitro susceptibility reports to assess the potential effectiveness of an antibacterial agent against a specific pathogen. This article presents examples of the utility of these concepts in terms of optimal clinical use of common antibacterials as well as more informed interpretation of the in vitro literature.
ISSN:0012-6667
1179-1950
DOI:10.2165/00003495-200161020-00001