An in vitro study of the efficacy of rifampicin and minocycline coated umbilical venous catheters

The use of antibiotic coated catheters has been proposed as a means of reducing catheter related sepsis. In this study, an in vitro comparison of bacterial colonisation rates was made between uncoated umbilical venous catheters and catheters coated with rifampicin and minocycline. The following para...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2001-03, Vol.17 (3), p.237-240
Main Authors: Norton, R.E., Patole, S., Whitehall, J.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics, Antitubercular - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial Infections - prevention & control
Biological and medical sciences
Candida albicans - drug effects
Candidiasis - prevention & control
Catheters, Indwelling - microbiology
Colony Count, Microbial
Drug Combinations
Gram-Negative Bacteria - drug effects
Gram-Negative Bacteria - growth & development
Gram-Positive Bacteria - drug effects
Gram-Positive Bacteria - growth & development
Humans
Medical sciences
Minocycline
Minocycline - pharmacology
Pharmacology. Drug treatments
Rifampicin
Rifampin - pharmacology
Time Factors
Umbilical catheters
Umbilical Veins
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Summary:The use of antibiotic coated catheters has been proposed as a means of reducing catheter related sepsis. In this study, an in vitro comparison of bacterial colonisation rates was made between uncoated umbilical venous catheters and catheters coated with rifampicin and minocycline. The following parameters were determined; the direct antimicrobial effect of coated and uncoated catheter segments against a range of organisms associated with line sepsis, the assessment of the decline in antimicrobial activity in coated catheters immersed in plasma and the inhibitory efficacy of the catheters to colonisation over a 28-day period. Minocycline and rifampicin coated umbilical catheters showed a superior inhibitory effect and prevented colonisation with the commoner line-related organisms, when compared with uncoated catheters. The inhibitory effect declined after 14 days in the human plasma. Resistance to colonisation in vitro may not extend beyond 21 days.
ISSN:0924-8579
1872-7913
DOI:10.1016/S0924-8579(00)00339-3