Antigenic and Genetic Characterization of Swine Influenza A (H1N1) Viruses Isolated from Pneumonia Patients in The Netherlands

It is generally believed that pigs can serve as an intermediate host for the transmission of avian influenza viruses to humans or as mixing vessels for the generation of avian–human reassortant viruses. Here we describe the antigenic and genetic characterization of two influenza A (H1N1) viruses, wh...

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Bibliographic Details
Published in:Virology (New York, N.Y.) N.Y.), 2001-04, Vol.282 (2), p.301-306
Main Authors: Rimmelzwaan, G.F., de Jong, J.C., Bestebroer, T.M., van Loon, A.M., Claas, E.C.J., Fouchier, R.A.M., Osterhaus, A.D.M.E.
Format: Article
Language:English
Subjects:
Adult
Animals
Avian influenza virus
Cell Line
Child, Preschool
Female
Ferrets
Hemagglutination Inhibition Tests
Humans
Immune Sera - immunology
Influenza A virus
Influenza A virus - genetics
Influenza A virus - immunology
Influenza A virus - isolation & purification
Influenza A virus - metabolism
Influenza A Virus, H1N1 Subtype
Likelihood Functions
Male
Molecular Sequence Data
Netherlands
Phylogeny
Pneumonia, Viral - transmission
Pneumonia, Viral - virology
Sequence Homology, Nucleic Acid
Swine - virology
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Summary:It is generally believed that pigs can serve as an intermediate host for the transmission of avian influenza viruses to humans or as mixing vessels for the generation of avian–human reassortant viruses. Here we describe the antigenic and genetic characterization of two influenza A (H1N1) viruses, which were isolated in The Netherlands from two patients who suffered from pneumonia. Both viruses proved to be antigenically and genetically similar to avian-like swine influenza A (H1N1) viruses which currently circulate in European pigs. It is concluded that European swine H1N1 viruses can infect humans directly, causing serious disease without the need for any reassortment event.
ISSN:0042-6822
1096-0341
DOI:10.1006/viro.2000.0810