Plasma Vascular Endothelial Growth Factor Concentrations in Healthy Dogs and Dogs with Hemangiosarcoma

Vascular endothelial growth factor (VEGF) is a dimeric glycosylated polypeptide growth factor with potent angiogenic, mitogenic, and vascular permeability‐enhancing properties specific for endothelial cells. In humans, VEGF seems to play a major role in tumor growth, and plasma concentrations correl...

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Published in:Journal of veterinary internal medicine 2001-03, Vol.15 (2), p.131-135
Main Authors: Clifford, Craig A., Hughes, Dez, Beal, Matthew W., Mackin, Andrew J., Henry, Carolyn J., Shofer, Frances S., Sorenmo, Karin U.
Format: Article
Language:English
Subjects:
Angiogenesis
Angiogenic factors
Animals
Cancer
Canine
Case-Control Studies
Dog Diseases - blood
Dogs - blood
Endothelial Growth Factors - blood
Enzyme-linked immunosorbent assay
Enzyme-Linked Immunosorbent Assay - veterinary
Female
Hemangiosarcoma - blood
Hemangiosarcoma - veterinary
Lymphokines - blood
Male
Neovascularization, Pathologic - veterinary
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
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Summary:Vascular endothelial growth factor (VEGF) is a dimeric glycosylated polypeptide growth factor with potent angiogenic, mitogenic, and vascular permeability‐enhancing properties specific for endothelial cells. In humans, VEGF seems to play a major role in tumor growth, and plasma concentrations correlate with tumor burden, response to therapy, and disease progression. This study compared plasma VEGF concentrations in healthy client‐owned dogs (n = 17) to dogs with hemangiosarcoma (HSA; n = 16). Dogs with HSA were significantly more likely to have detectable concentrations of plasma VEGF (13/17) compared to healthy dogs (1/17; P < .001). The median plasma VEGF concentration for dogs with HSA was 17.2 pg/mL (range,
ISSN:0891-6640
1939-1676
DOI:10.1111/j.1939-1676.2001.tb01244.x