Automated synthesis and purification of [ 18F]bromofluoromethane at high specific radioactivity

[ 18F]Bromofluoromethane was synthesised from dibromomethane by substitution of bromine with [ 18F]fluoride. The synthesis and separation of the [ 18F]bromofluoromethane were automated. [ 18F]Bromofluoromethane was used to convert a phenolic and a thiophenolic precursor into a labelled ether and thi...

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Bibliographic Details
Published in:Applied radiation and isotopes 2001-06, Vol.54 (6), p.927-933
Main Authors: Bergman, Jörgen, Eskola, Olli, Lehikoinen, Pertti, Solin, Olof
Format: Article
Language:English
Subjects:
18F
[ 18F]bromofluoromethane
Automation - instrumentation
Automation - methods
Chromatography, High Pressure Liquid
Cyclotrons
Fluorine Radioisotopes
Hydrocarbons, Brominated - chemical synthesis
Hydrocarbons, Fluorinated - chemical synthesis
Indicators and Reagents
LC-MS
Mass Spectrometry
Specific radioactivity
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Description
Summary:[ 18F]Bromofluoromethane was synthesised from dibromomethane by substitution of bromine with [ 18F]fluoride. The synthesis and separation of the [ 18F]bromofluoromethane were automated. [ 18F]Bromofluoromethane was used to convert a phenolic and a thiophenolic precursor into a labelled ether and thioether, respectively. The specific radioactivity of these labelled products was determined with both high-performance liquid chromatography (with UV-absorbance detection) and liquid chromatography (with mass spectrometric detection). The median for the specific radioactivity, corrected at the end of radionuclide production, was 934 GBq/μmol (range 40–9900 GBq/μmol; n=83).
ISSN:0969-8043
1872-9800
DOI:10.1016/S0969-8043(00)00358-4