Programmed T-cell death in experimental chagas disease

In mature T cells, programmed cell death is thought to serve a regulatory function by limiting both the duration and amplitude of immune responses. Programmed cell death might also be involved in immuno-pathogenesis of certain infectious diseases: recent evidence suggests that programmed T-cell deat...

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Bibliographic Details
Published in:Parasitology today (Regular ed.) 1995-10, Vol.11 (10), p.391-394
Main Authors: DosReis, G.A., Fonseca, M.E.F., Lopes, M.F.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Experimental protozoal diseases and models
Infectious diseases
Medical sciences
Parasitic diseases
Protozoal diseases
Trypanosoma cruzi
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Summary:In mature T cells, programmed cell death is thought to serve a regulatory function by limiting both the duration and amplitude of immune responses. Programmed cell death might also be involved in immuno-pathogenesis of certain infectious diseases: recent evidence suggests that programmed T-cell death plays an important role in immune suppression during viral infections. In this article, George DosReis, Maria Evangelina Fonseca and Marcela Lopes review their findings on programmed T-cell death in experimental infection induced by the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease. They also discuss the differential behavior of CD4 + and CD8 + T-cell subsets regarding programmed cell death, and same possible pathogenic aspects of host-parasite interaction, where abnormal or exaggerated programmed T-cell death could be involved.
ISSN:0169-4758
1873-1473
DOI:10.1016/0169-4758(95)80011-5