Arteriovenous carbon dioxide and pH gradients during cardiac arrest

In a porcine preparation of cardiac arrest, we demonstrated that there is a marked paradox of venous acidemia and arterial alkalemia. This paradox is related to decreased clearance of CO2 from the lungs when pulmonary blood flow is critically reduced. Accordingly, increased venous PCO2 rather than m...

Full description

Saved in:
Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1986-11, Vol.74 (5), p.1071-1074
Main Authors: GRUNDLER, W, WEIL, M. H, RACKOW, E. C
Format: Article
Language:English
Subjects:
Acid-Base Equilibrium
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Arteries
Biological and medical sciences
Blood Pressure
Carbon Dioxide - blood
Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care
Heart Arrest - blood
Heart Arrest - metabolism
Heart Arrest - physiopathology
Hydrogen-Ion Concentration
Intensive care medicine
Lactates - blood
Medical sciences
Resuscitation
Swine
Swine, Miniature
Veins
Ventricular Fibrillation - blood
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In a porcine preparation of cardiac arrest, we demonstrated that there is a marked paradox of venous acidemia and arterial alkalemia. This paradox is related to decreased clearance of CO2 from the lungs when pulmonary blood flow is critically reduced. Accordingly, increased venous PCO2 rather than metabolic acidosis due to lactic acidosis predominates during the initial 8 min of cardiopulmonary resuscitation. Arterial blood gases fail as indicators of systemic acid-base status and therefore as indicators of tissue acidosis.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.74.5.1071