Pilot histologic and ultrastructural study of the effects of medium-depth chemical facial peels on dermal collagen in patients with actinically damaged skin

Background: Chemical peels are employed for a variety of benign and premalignant skin disorders. Objective: We compared clinical and histologic features with ultrastructural changes that occur after medium-depth chemical facial peel. Methods: Three men with actinically damaged facial skin underwent...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 1995-03, Vol.32 (3), p.472-478
Main Authors: Nelson, Bruce R, Fader, Darrell J, Gillard, Montgomery, Majmudar, Gopa, Johnson, Timothy M
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Chemexfoliation - methods
Collagen - ultrastructure
Humans
Injuries of the skin. Diseases of the skin due to physical agents
Male
Medical sciences
Microscopy, Electron
Middle Aged
Pilot Projects
Skin - pathology
Skin - ultrastructure
Skin Aging - pathology
Traumas. Diseases due to physical agents
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Summary:Background: Chemical peels are employed for a variety of benign and premalignant skin disorders. Objective: We compared clinical and histologic features with ultrastructural changes that occur after medium-depth chemical facial peel. Methods: Three men with actinically damaged facial skin underwent a single 35% trichloroacetic acid peel. Biopsy specimens were taken before the peel, and 2 weeks and 3 months after the peel, for histologic examination, electron microscopy, and gel electrophoresis to assess total collagen type I content. Results: Clinical resolution of actinic damage corresponded with restoration of epidermal polarity. Collagen type I was markedly increased after the peel. Characteristic ultrastructural features of skin after peeling include markedly decreased epidermal intracytoplasmic vacuoles, decreased elastic fibers, and increased activated fibroblasts. Conclusion: Electron microscopic studies after a medium-depth chemical peel of photodamaged skin reveal more profound changes than those seen histologically.
ISSN:0190-9622
1097-6787
DOI:10.1016/0190-9622(95)90072-1