Safety And Immunogenicity Of An Inactivated Hepatitis A Vaccine In Preschool Children

Young children in day care centers are an important source of hepatitis A virus (HAV) infection. The safety and immunogenicity of an inactivated HAV vaccine was evaluated in 57 children in day care centers. Nonimmune healthy children were given 0.5 mL of vaccine with subsequent doses: group A (28 ch...

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Bibliographic Details
Published in:The Journal of infectious diseases 1995-03, Vol.171 (Supplement-1), p.S70-S72
Main Authors: Balcarek, Kytia B., Regina Bagley, M., Pass, Robert F., Schiff, Eugene R., Krause, David S.
Format: Article
Language:English
Subjects:
Antibodies
Biological and medical sciences
Child Day Care Centers
Child, Preschool
Day care centers
Disease outbreaks
Dosage
Epidemiology
Hepatitis A Antibodies
Hepatitis A Vaccines
Hepatitis A virus
Hepatitis A Virus, Human - immunology
Hepatitis Antibodies - blood
Human viral diseases
Humans
Immunization Schedule
Infections
Infectious diseases
Medical sciences
Preschool children
Vaccination
Vaccines, Inactivated - administration & dosage
Vaccines, Inactivated - adverse effects
Vaccines, Inactivated - immunology
Viral diseases
Viral hepatitis
Viral Hepatitis Vaccines - administration & dosage
Viral Hepatitis Vaccines - adverse effects
Viral Hepatitis Vaccines - immunology
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Summary:Young children in day care centers are an important source of hepatitis A virus (HAV) infection. The safety and immunogenicity of an inactivated HAV vaccine was evaluated in 57 children in day care centers. Nonimmune healthy children were given 0.5 mL of vaccine with subsequent doses: group A (28 children), second and third doses 1 and 2 months after the first; group B (29 children), second and third doses at 1 and 6 months. Antibody to HAV was measured before each dose and 8 months after the initial dose. All children developed antibody to HAV. Groups A and B had similar levels of antibody at 2 months; levels were lower in group B before the third dose and higher 8 months after the first dose. Local reactions after vaccination were reported in 17 children (29.8%). Minor systemic side effects that cleared spontaneously were observed in 27 children (47%).
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/171.Supplement_1.S70