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Vitamin E deficiency in the pathogenesis of haemolysis and hyperbilirubinaemia of neonatal jaundice

A study involving 37 jaundiced neonates (ages 1-19 days) and 29 normal neonate controls assessed whether vitamin E deficiency plays a role in the onset of neonatal jaundice. Blood analyses revealed significantly low levels of vitamin E and glucose-6-phosphate dehydrogenase (G6PD) activity with conco...

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Bibliographic Details
Published in:Journal of tropical pediatrics (1980) 1986-10, Vol.32 (5), p.251-254
Main Authors: Ojo, C.O, Dawodu, A.H, Osifo, B.O.A
Format: Article
Language:English
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Summary:A study involving 37 jaundiced neonates (ages 1-19 days) and 29 normal neonate controls assessed whether vitamin E deficiency plays a role in the onset of neonatal jaundice. Blood analyses revealed significantly low levels of vitamin E and glucose-6-phosphate dehydrogenase (G6PD) activity with concomitant elevations of unconjugated bilirubin and percent hemolysis. Negative correlations in jaundice were found between vitamin E and bilirubin and between vitamin E and percent hemolysis, and a positive relation was found between vitamin E and G6PD. The results indicate that the increase in hemolysis and bilirubin may be due to a vitamin E deficiency, particularly in G6PD-deficient erythrocytes.(wz)
ISSN:0142-6338
1465-3664
DOI:10.1093/tropej/32.5.251