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Vitamin E deficiency in the pathogenesis of haemolysis and hyperbilirubinaemia of neonatal jaundice
A study involving 37 jaundiced neonates (ages 1-19 days) and 29 normal neonate controls assessed whether vitamin E deficiency plays a role in the onset of neonatal jaundice. Blood analyses revealed significantly low levels of vitamin E and glucose-6-phosphate dehydrogenase (G6PD) activity with conco...
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Published in: | Journal of tropical pediatrics (1980) 1986-10, Vol.32 (5), p.251-254 |
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Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
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Summary: | A study involving 37 jaundiced neonates (ages 1-19 days) and 29 normal neonate controls assessed whether vitamin E deficiency plays a role in the onset of neonatal jaundice. Blood analyses revealed significantly low levels of vitamin E and glucose-6-phosphate dehydrogenase (G6PD) activity with concomitant elevations of unconjugated bilirubin and percent hemolysis. Negative correlations in jaundice were found between vitamin E and bilirubin and between vitamin E and percent hemolysis, and a positive relation was found between vitamin E and G6PD. The results indicate that the increase in hemolysis and bilirubin may be due to a vitamin E deficiency, particularly in G6PD-deficient erythrocytes.(wz) |
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ISSN: | 0142-6338 1465-3664 |
DOI: | 10.1093/tropej/32.5.251 |