Stimulus-evoked dopamine overflow in the rat nucleus accumbens is decreased following chronic haloperidol administration: an in vivo voltammetric study

Fast cyclic voltammetry was used to investigate the effects of chronic haloperidol (HAL) treatment on electrically evoked dopamine (DA) overflow in the nucleus accumbens of the anaesthetized rat in vivo. Evoked DA efflux was significantly reduced in rats treated with 1.0 mg/kg per day HAL for 21 day...

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Bibliographic Details
Published in:Neuroscience letters 1995-01, Vol.183 (1), p.91-95
Main Authors: Feasey-Truger, Karin J., Earl, Christopher D., Alzheimer, Christian, ten Bruggencate, Gerrit
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chronic treatment
Dopamine
Dopamine - metabolism
Electric Stimulation
Haloperidol
Haloperidol - pharmacology
In vivo fast cyclic voltammetry
Injections, Intraperitoneal
Male
Medical sciences
Neuropharmacology
Nucleus accumbens
Nucleus Accumbens - drug effects
Pharmacology. Drug treatments
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rat
Rats
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Summary:Fast cyclic voltammetry was used to investigate the effects of chronic haloperidol (HAL) treatment on electrically evoked dopamine (DA) overflow in the nucleus accumbens of the anaesthetized rat in vivo. Evoked DA efflux was significantly reduced in rats treated with 1.0 mg/kg per day HAL for 21 days. In rats treated with 0.5 mg/kg per day, evoked DA overflow was reduced, but did not differ significantly from control values. In untreated animals, injection of a single dose of HAL resulted in a significant increase in the DA overflow evoked by subsequent stimulus trains. In contrast, this HAL challenge did not produce a significant enhancement in evoked DA overflow in any of the. HAL-treated groups. These results are consistent with the previous reports that basal DA release is reduced after chronic HAL treatment, and show for the first time that chronic HAL administration decreases stimulus-evoked DA overflow in the rat nucleus accumbens in vivo.
ISSN:0304-3940
1872-7972
DOI:10.1016/0304-3940(94)11122-Y