Acetyl- l-carnitine corrects the altered peripheral nerve function of experimental diabetes

• Published in: Metabolism, clinical and experimental clinical and experimental, 1995-05, Vol.44 (5), p.677-680
• Main Authors: Lowitt, S., Malone, J.I., Salem, A.F., Korthals, J., Benford, S.
• Format: Article
• Language: English
• Subjects: Acetylcarnitine - therapeutic use; Aldehyde Reductase - antagonists & inhibitors; Animals; Associated diseases and complications; BIOCHEMICAL PATHWAYS; Biological and medical sciences; CARNITINA; CARNITINE; DIABETE; DIABETES; Diabetes Mellitus, Experimental - physiopathology; Diabetes. Impaired glucose tolerance; Diabetic Neuropathies - drug therapy; Diabetic Neuropathies - physiopathology; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; EXPERIMENTACION; EXPERIMENTATION; HIPERGLICEMIA; HYPERGLYCAEMIA; HYPERGLYCEMIA; HYPERGLYCEMIE; Imidazoles - therapeutic use; Imidazolidines; Male; Medical sciences; Muscle, Skeletal - innervation; NERF; NERVES; NERVIOS; Neural Conduction - drug effects; POLIALCOHOLES; POLYOL; POLYOLS; RAT; RATA; RATS; Rats, Wistar; Sciatic Nerve - drug effects; Sciatic Nerve - physiology; Sciatic Nerve - physiopathology; VIA BIOQUIMICA DEL METABOLISMO; VOIE BIOCHIMIQUE DU METABOLISME
• ISSN: 0026-0495; 1532-8600
• DOI: 10.1016/0026-0495(95)90128-0

Acetyl- l-carnitine (ALC) has been shown to facilitate the repair of transected sciatic nerves. The effect of ALC (50 mg/kg/d) on the diminished nerve conduction velocity (NCV) of rats with streptozotocin (STZ)-induced hyperglycemia of 3 weeks' duration was evaluated. The aldose reductase inhibitor, sorbinil, which is reported to normalize the impaired NCV associated with experimental diabetes, was used as a positive control. Aldose reductase inhibitors are thought to have an effect by decreasing peripheral nerve sorbitol content and increasing nerve myo-inositol. Treatment of STZ-diabetic rats with either ALC or sorbinil resulted in normal NCV. Sorbinil treatment was associated with normalized sciatic nerve sorbitol and myo-inositol; ALC treatment did not reduce the elevated sorbitol levels, but sciatic nerve myo-inositol content was no different from nondiabetic levels. Both ALC and sorbinil treatment of STZ-diabetic rats were associated with a reduction in the elevated malondialdehyde (MDA) content of diabetic sciatic nerve, indicating reduced lipid peroxidation. The beneficial effects of sorbinil and ALC on the altered peripheral nerve function associated with diabetes were similar, but their effects on the polyol pathway (frequently implicated in the pathogenesis of peripheral neuropathy) were different.