Serotonin receptor binding in a colony model of chronic social stress

Male rats housed in mixed-sex groups quickly established dominance hierarchies in which subordinates appeared severely stressed. Subordinate rats had elevated basal corticosterone (CORT) levels relative to dominants and individually housed controls. Several subordinates had blunted CORT responses to...

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Bibliographic Details
Published in:Biological psychiatry (1969) 1995-03, Vol.37 (6), p.383-393
Main Authors: McKittrick, Christina R., Caroline Blanchard, D., Blanchard, Robert J., McEwen, Bruce S., Sakai, Randall R.
Format: Article
Language:English
Subjects:
5-HT 1A receptor
5-HT 2 receptor
8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacokinetics
Adult and adolescent clinical studies
Animals
Arousal - physiology
Autoradiography
Biological and medical sciences
Brain - metabolism
corticosterone
Corticosterone - blood
Depression
dominance
Dominance-Subordination
Female
Iodocyanopindolol
Ketanserin - analogs & derivatives
Ketanserin - pharmacokinetics
Male
Medical sciences
Mood disorders
Pindolol - analogs & derivatives
Pindolol - pharmacokinetics
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Rats
Receptors, Serotonin - classification
Receptors, Serotonin - physiology
serotonin
Social Environment
Stress
Stress, Psychological - complications
subordination
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Summary:Male rats housed in mixed-sex groups quickly established dominance hierarchies in which subordinates appeared severely stressed. Subordinate rats had elevated basal corticosterone (CORT) levels relative to dominants and individually housed controls. Several subordinates had blunted CORT responses to a novel stressor, leading to the classification of subordinates as either stress-responsive or nonresponsive. Binding to 5-HT 1A receptors was reduced in stress-responsive subordinates compared to controls throughout hippocampus and dentate gyrus. Decreased binding was observed in nonresponsive subordinates only in CA3 of hippocampus. In addition, 5-HT 1A binding was decreased in CA1, CA3, and CA4 in dominants compared to controls. Binding to 5-HT 2 receptors was increased in parietal cortex in both responsive and nonresponsive subordinates compared to controls. No changes were observed in binding to 5-HT 1B receptors. These results are discussed in the context of regulation of the serotonergic system by stress and glucocorticoids and possible relevance to the pathophysiology of depression.
ISSN:0006-3223
1873-2402
DOI:10.1016/0006-3223(94)00152-S