Cerebral blood flow and EEG changes in preterm infants with patent ductus arteriosus

It is unknown whether the decreased cerebral blood flow seen in infants with a large patent ductus arteriosus is associated with cerebral dysfunction. Decreased cerebral blood flow in adult human and animal models has been associated with altered electroencephalography (EEG), spectral-analyzed EEG,...

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Bibliographic Details
Published in:Pediatric neurology 1995-02, Vol.12 (2), p.114-119
Main Authors: Kurtis, Peter S., Rosenkrantz, Ted S., Zalneraitis, Edwin L.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood Flow Velocity - physiology
Brain - blood supply
Brain - physiopathology
Cardiology. Vascular system
Cerebral Cortex - blood supply
Cerebral Cortex - physiopathology
Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava
Ductus Arteriosus, Patent - physiopathology
Ductus Arteriosus, Patent - surgery
Electroencephalography - instrumentation
Female
Follow-Up Studies
Fourier Analysis
Heart
Humans
Infant, Newborn
Infant, Premature, Diseases - physiopathology
Infant, Premature, Diseases - surgery
Male
Medical sciences
Photic Stimulation
Postoperative Complications - physiopathology
Reference Values
Signal Processing, Computer-Assisted - instrumentation
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Summary:It is unknown whether the decreased cerebral blood flow seen in infants with a large patent ductus arteriosus is associated with cerebral dysfunction. Decreased cerebral blood flow in adult human and animal models has been associated with altered electroencephalography (EEG), spectral-analyzed EEG, and EEG response to photic stimulation. Cerebral blood flow velocity, EEG, spectral analysis of EEG, and photic alteration of EEG spectra were evaluated in 8 infants before and after closure of a significant patent ductus arteriosus and in 10 control infants without a patent ductus arteriosus. All infants with patent ductus arteriosus had moderate or large shunts associated with a 25% mean reduction in cerebral blood flow velocity. There were no differences, however, in EEG, spectral analysis of EEG, or photic alteration of the spectral analysis for these infants before and after patent ductus arteriosus closure as compared to controls. It is concluded that the degree of decreased cerebral blood flow in infants with a significant patent ductus arteriosus is not sufficient to cause measurable alteration in electrocortical activity.
ISSN:0887-8994
1873-5150
DOI:10.1016/0887-8994(94)00150-Z