Randomized, prospective study of cyanoacrylate injection, sclerotherapy, or rubber band ligation for endoscopic hemostasis of bleeding canine gastric varices

The purpose of this randomized, nonblinded study was to compare the effectiveness, safety, and technical ease of three different endoscopic techniques for the treatment of bleeding gastric varices in a canine model. Twenty dogs with large, bleeding gastric varices underwent endoscopic hemostasis wit...

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Bibliographic Details
Published in:Gastrointestinal endoscopy 1995-03, Vol.41 (3), p.201-205
Main Authors: Jutabha, Rome, Jensen, Dennis M., Egan, James, Machicado, Gustavo A., Hirabayashi, Kenneth
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Dogs
Enbucrilate - administration & dosage
Enbucrilate - analogs & derivatives
Esophageal and Gastric Varices - therapy
Esophagoscopy
Gastrointestinal Hemorrhage - therapy
Hemostatic Techniques
Ligation - methods
Medical sciences
Recurrence
Sclerotherapy - methods
Sodium Tetradecyl Sulfate - administration & dosage
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology. Biomaterials. Equipments
Treatment Outcome
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Summary:The purpose of this randomized, nonblinded study was to compare the effectiveness, safety, and technical ease of three different endoscopic techniques for the treatment of bleeding gastric varices in a canine model. Twenty dogs with large, bleeding gastric varices underwent endoscopic hemostasis with rubber band ligation, sclerotherapy, and cyanoacrylate injection. The time and number of attempts required to achieve definitive hemostasis were evaluated for each technique, and each method was assessed for ease of use. Ulceration rates, ulcer size and depth, and stigmata of ulcer hemorrhage were assessed at 1 week. Intravariceal sclerotherapy was the fastest and easiest to perform. Rubber band ligation was intermediate in technical ease, but it caused the largest and deepest ulcers and had the highest rates of stigmata of ulcer hemorrhage and secondary bleeding. Cyanoacrylate injection was the most cumbersome endoscopic method to perform. All three treatments were effective for controlling gastric variceal bleeding. Intravariceal sclerotherapy had the most favorable results overall because of its technical ease, efficacy, and modest complication rates. (Gastrointest Endosc 1995;41:201-5.)
ISSN:0016-5107
1097-6779
DOI:10.1016/S0016-5107(95)70338-1