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Compartmentalization of Cells Bearing “Rheumatic” Cell Surface Antigens in Peripheral Blood and Tonsils in Rheumatic Heart Disease

Monoclonal antibodies that recognize “rheumatic” antigens of peripheral blood non-T cells were used to study the compartmentalization of such cells in peripheral blood and tonsils of individuals with rheumatic heart disease (RHD) and suitable control subjects. The peripheral blood of most (71%) of t...

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Published in:	The Journal of infectious diseases 1987-02, Vol.155 (2), p.247-252
Main Authors:	Gray, E. D., Regelmann, W. E., Abdin, Z., Kholy, A. EI, Zaher, S., Kamel, R., Mansour, M., Miller, L., Ferrieri, P., Zabriskie, J. B., Braun, D.
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Language:	English
Subjects:	Adolescent Antibodies Antigens Antigens, Surface - analysis B lymphocytes Bacterial diseases Biological and medical sciences Blood Child Control groups Heart diseases Human bacterial diseases Humans Infectious diseases Lymphocytes - immunology Medical sciences Monoclonal antibodies Original Articles Palatine Tonsil - immunology Palatine tonsils Rheumatic heart disease Rheumatic Heart Disease - blood Rheumatic Heart Disease - immunology Staphylococcal infections, streptococcal infections, pneumococcal infections T lymphocytes Tonsillitis - blood Tonsillitis - immunology
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container_title	The Journal of infectious diseases
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creator	Gray, E. D. Regelmann, W. E. Abdin, Z. Kholy, A. EI Zaher, S. Kamel, R. Mansour, M. Miller, L. Ferrieri, P. Zabriskie, J. B. Braun, D.
description	Monoclonal antibodies that recognize “rheumatic” antigens of peripheral blood non-T cells were used to study the compartmentalization of such cells in peripheral blood and tonsils of individuals with rheumatic heart disease (RHD) and suitable control subjects. The peripheral blood of most (71%) of the 42 individuals with RHD contained cells reacting with monoclonal antibody 83S19.23 or 256S.10, whereas these cells were present in only 17% of the 41 control subjects (P < .02). However, none of 21 individuals with RHD had such cells in their tonsils, although they were present in the tonsils of 50% of the 40 control subjects (P < .03). These results may reflect a failure in RHD of organ-specific homing of cells with the epitopes recognized by the antibodies. The presence of these cells in tonsils may be important in the immune response to streptococcal pharyngeal infection, and their absence in RHD may be involved in the unusual immune responses characteristic of this disease.
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D. ; Regelmann, W. E. ; Abdin, Z. ; Kholy, A. EI ; Zaher, S. ; Kamel, R. ; Mansour, M. ; Miller, L. ; Ferrieri, P. ; Zabriskie, J. B. ; Braun, D.</creator><creatorcontrib>Gray, E. D. ; Regelmann, W. E. ; Abdin, Z. ; Kholy, A. EI ; Zaher, S. ; Kamel, R. ; Mansour, M. ; Miller, L. ; Ferrieri, P. ; Zabriskie, J. B. ; Braun, D.</creatorcontrib><description>Monoclonal antibodies that recognize “rheumatic” antigens of peripheral blood non-T cells were used to study the compartmentalization of such cells in peripheral blood and tonsils of individuals with rheumatic heart disease (RHD) and suitable control subjects. The peripheral blood of most (71%) of the 42 individuals with RHD contained cells reacting with monoclonal antibody 83S19.23 or 256S.10, whereas these cells were present in only 17% of the 41 control subjects (P < .02). However, none of 21 individuals with RHD had such cells in their tonsils, although they were present in the tonsils of 50% of the 40 control subjects (P < .03). These results may reflect a failure in RHD of organ-specific homing of cells with the epitopes recognized by the antibodies. The presence of these cells in tonsils may be important in the immune response to streptococcal pharyngeal infection, and their absence in RHD may be involved in the unusual immune responses characteristic of this disease.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/155.2.247</identifier><identifier>PMID: 3805764</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adolescent ; Antibodies ; Antigens ; Antigens, Surface - analysis ; B lymphocytes ; Bacterial diseases ; Biological and medical sciences ; Blood ; Child ; Control groups ; Heart diseases ; Human bacterial diseases ; Humans ; Infectious diseases ; Lymphocytes - immunology ; Medical sciences ; Monoclonal antibodies ; Original Articles ; Palatine Tonsil - immunology ; Palatine tonsils ; Rheumatic heart disease ; Rheumatic Heart Disease - blood ; Rheumatic Heart Disease - immunology ; Staphylococcal infections, streptococcal infections, pneumococcal infections ; T lymphocytes ; Tonsillitis - blood ; Tonsillitis - immunology</subject><ispartof>The Journal of infectious diseases, 1987-02, Vol.155 (2), p.247-252</ispartof><rights>Copyright 1987 University of Chicago</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-1dadd272f3621e6246add9a9406093d865c9cfdc760dff3bf4607d7e61858dcd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8012377$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3805764$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gray, E. D.</creatorcontrib><creatorcontrib>Regelmann, W. E.</creatorcontrib><creatorcontrib>Abdin, Z.</creatorcontrib><creatorcontrib>Kholy, A. EI</creatorcontrib><creatorcontrib>Zaher, S.</creatorcontrib><creatorcontrib>Kamel, R.</creatorcontrib><creatorcontrib>Mansour, M.</creatorcontrib><creatorcontrib>Miller, L.</creatorcontrib><creatorcontrib>Ferrieri, P.</creatorcontrib><creatorcontrib>Zabriskie, J. B.</creatorcontrib><creatorcontrib>Braun, D.</creatorcontrib><title>Compartmentalization of Cells Bearing “Rheumatic” Cell Surface Antigens in Peripheral Blood and Tonsils in Rheumatic Heart Disease</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Monoclonal antibodies that recognize “rheumatic” antigens of peripheral blood non-T cells were used to study the compartmentalization of such cells in peripheral blood and tonsils of individuals with rheumatic heart disease (RHD) and suitable control subjects. The peripheral blood of most (71%) of the 42 individuals with RHD contained cells reacting with monoclonal antibody 83S19.23 or 256S.10, whereas these cells were present in only 17% of the 41 control subjects (P < .02). However, none of 21 individuals with RHD had such cells in their tonsils, although they were present in the tonsils of 50% of the 40 control subjects (P < .03). These results may reflect a failure in RHD of organ-specific homing of cells with the epitopes recognized by the antibodies. The presence of these cells in tonsils may be important in the immune response to streptococcal pharyngeal infection, and their absence in RHD may be involved in the unusual immune responses characteristic of this disease.</description><subject>Adolescent</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>Antigens, Surface - analysis</subject><subject>B lymphocytes</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Child</subject><subject>Control groups</subject><subject>Heart diseases</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Lymphocytes - immunology</subject><subject>Medical sciences</subject><subject>Monoclonal antibodies</subject><subject>Original Articles</subject><subject>Palatine Tonsil - immunology</subject><subject>Palatine tonsils</subject><subject>Rheumatic heart disease</subject><subject>Rheumatic Heart Disease - blood</subject><subject>Rheumatic Heart Disease - immunology</subject><subject>Staphylococcal infections, streptococcal infections, pneumococcal infections</subject><subject>T lymphocytes</subject><subject>Tonsillitis - blood</subject><subject>Tonsillitis - immunology</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><recordid>eNqFkbtuFDEUhi0ECkugp0Fygehm47tnymQTWKSVQBAkRGM5viQOM_Ziz0iBKhVPkbxcngSTXRY6Ksv6_vNJ5_wAPMdojlFHD0L0NpQDzPmczAmTD8AMcyobITB9CGYIEdLgtusegyelXCKEGBVyD-zRFnEp2Az8XKRhrfM4uDjqPvzQY0gRJg8Xru8LPHI6h3gO765vPly4aajY3F3f3lP4ccpeGwcP4xjOXSwwRPje5bC-cFn38KhPyUIdLTxNsYT-nu8scFnVIzwOxeninoJHXvfFPdu---DT65PTxbJZvXvzdnG4agzDbGyw1dYSSTwVBDtBmKj_TncMiXoN2wpuOuOtkQJZ7-mZZwJJK53ALW-tsXQfvNp41zl9m1wZ1RCKqcvo6NJUlJRUtl290v-CmLWsowzXINoETU6lZOfVOodB5-8KI_W7I7XpSNWOFFG1ozryYuuezgZndwPbUip_ueW6GN37rKOpgj-xFmFC5T-ayzKm_NeCMOI1U3mz4aGM7mrHdf6qRF2Tq-XnL4rKYy5WnChBfwFgKrbo</recordid><startdate>19870201</startdate><enddate>19870201</enddate><creator>Gray, E. D.</creator><creator>Regelmann, W. E.</creator><creator>Abdin, Z.</creator><creator>Kholy, A. EI</creator><creator>Zaher, S.</creator><creator>Kamel, R.</creator><creator>Mansour, M.</creator><creator>Miller, L.</creator><creator>Ferrieri, P.</creator><creator>Zabriskie, J. B.</creator><creator>Braun, D.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19870201</creationdate><title>Compartmentalization of Cells Bearing “Rheumatic” Cell Surface Antigens in Peripheral Blood and Tonsils in Rheumatic Heart Disease</title><author>Gray, E. D. ; Regelmann, W. E. ; Abdin, Z. ; Kholy, A. EI ; Zaher, S. ; Kamel, R. ; Mansour, M. ; Miller, L. ; Ferrieri, P. ; Zabriskie, J. 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B.</au><au>Braun, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Compartmentalization of Cells Bearing “Rheumatic” Cell Surface Antigens in Peripheral Blood and Tonsils in Rheumatic Heart Disease</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1987-02-01</date><risdate>1987</risdate><volume>155</volume><issue>2</issue><spage>247</spage><epage>252</epage><pages>247-252</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Monoclonal antibodies that recognize “rheumatic” antigens of peripheral blood non-T cells were used to study the compartmentalization of such cells in peripheral blood and tonsils of individuals with rheumatic heart disease (RHD) and suitable control subjects. The peripheral blood of most (71%) of the 42 individuals with RHD contained cells reacting with monoclonal antibody 83S19.23 or 256S.10, whereas these cells were present in only 17% of the 41 control subjects (P < .02). However, none of 21 individuals with RHD had such cells in their tonsils, although they were present in the tonsils of 50% of the 40 control subjects (P < .03). These results may reflect a failure in RHD of organ-specific homing of cells with the epitopes recognized by the antibodies. The presence of these cells in tonsils may be important in the immune response to streptococcal pharyngeal infection, and their absence in RHD may be involved in the unusual immune responses characteristic of this disease.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>3805764</pmid><doi>10.1093/infdis/155.2.247</doi><tpages>6</tpages></addata></record>
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subjects	Adolescent Antibodies Antigens Antigens, Surface - analysis B lymphocytes Bacterial diseases Biological and medical sciences Blood Child Control groups Heart diseases Human bacterial diseases Humans Infectious diseases Lymphocytes - immunology Medical sciences Monoclonal antibodies Original Articles Palatine Tonsil - immunology Palatine tonsils Rheumatic heart disease Rheumatic Heart Disease - blood Rheumatic Heart Disease - immunology Staphylococcal infections, streptococcal infections, pneumococcal infections T lymphocytes Tonsillitis - blood Tonsillitis - immunology
title	Compartmentalization of Cells Bearing “Rheumatic” Cell Surface Antigens in Peripheral Blood and Tonsils in Rheumatic Heart Disease
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