Dissection of memory formation: from behavioral pharmacology to molecular genetics

Behavioral pharmacology has suggested an intricate, multiphasic pathway of memory consolidation. An integrated molecular pharmacological approach in Drosophila has lent support to this theory recently by dissecting consolidated memory into two genetically distinct components: a cycloheximide-insensi...

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Bibliographic Details
Published in:Trends in Neurosciences 1995-05, Vol.18 (5), p.212-218
Main Authors: DeZazzo, Jim, Tully, Tim
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biological and medical sciences
Cyclic AMP - pharmacology
Cycloheximide - pharmacology
Drosophila
Fundamental and applied biological sciences. Psychology
General aspects. Models. Methods
Genes
Genetics
Insects
Memory
Memory - physiology
Molecular Biology
Neural Pathways - physiology
Neuropharmacology
Time Factors
Transcription Factors
Vertebrates: nervous system and sense organs
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Summary:Behavioral pharmacology has suggested an intricate, multiphasic pathway of memory consolidation. An integrated molecular pharmacological approach in Drosophila has lent support to this theory recently by dissecting consolidated memory into two genetically distinct components: a cycloheximide-insensitive, anesthesia-resistant memory and a cycloheximide-sensitive long-term memory. In addition, experiments using inducible dominant-negative transgenes in Drosophila or gene knockouts in mice demonstrates a role of cAMP-responsive transcription factors in formation of long-term memory. These studies support the application of reverse-genetic strategies, including the use of temporally specific agonists and antagonists, to advance the functional dissection of memory formation.
ISSN:0166-2236
1878-108X
DOI:10.1016/0166-2236(95)93905-D