Balmoralmycin, a New Angucyclinone, and Two Related Biosynthetic Shunt Products Containing a Novel Ring System

A new angucyclinone, named balmoralmycin (1), was isolated as an inhibitor of protein kinase C-α (PKC-α) from the Streptomyces strain P6417. Chemical screening of extracts of the same strain resulted in the detection of two decaketides with unusual structural features (2 and 3). Both compounds belon...

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Published in:Journal of antibiotics 1995/06/25, Vol.48(6), pp.457-461
Main Authors: BINDSEIL, KAI UWE, HUG, PAUL, PETER, HEINRICH H., PETERSEN, FRANK, ROGGO, BARBARA E.
Format: Article
Language:English
Subjects:
Anthracyclines
Antibiotics, Antineoplastic - chemistry
Antibiotics, Antineoplastic - isolation & purification
Antibiotics, Antineoplastic - pharmacology
Benzophenones - chemistry
Benzophenones - isolation & purification
Biological and medical sciences
Fermentation
Medical sciences
Miscellaneous
Molecular Structure
Naphthacenes - chemistry
Naphthacenes - isolation & purification
Pharmacology. Drug treatments
Protein Kinase C - antagonists & inhibitors
Pyrones - chemistry
Pyrones - isolation & purification
Streptomyces
Structure-Activity Relationship
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container_end_page 461
container_issue 6
container_start_page 457
container_title Journal of antibiotics
container_volume 48
creator BINDSEIL, KAI UWE
HUG, PAUL
PETER, HEINRICH H.
PETERSEN, FRANK
ROGGO, BARBARA E.
description A new angucyclinone, named balmoralmycin (1), was isolated as an inhibitor of protein kinase C-α (PKC-α) from the Streptomyces strain P6417. Chemical screening of extracts of the same strain resulted in the detection of two decaketides with unusual structural features (2 and 3). Both compounds belong to a recently described structural class of secondary metabolites which arises from engineered biosynthesis of a recombinant Streptomyces strain. The isolation of compounds of this class from a wild-type strain has never been reported before.
doi_str_mv 10.7164/antibiotics.48.457
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identifier ISSN: 0021-8820
ispartof The Journal of Antibiotics, 1995/06/25, Vol.48(6), pp.457-461
issn 0021-8820
1881-1469
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source J-STAGE (Free Access)英語
subjects Anthracyclines
Antibiotics, Antineoplastic - chemistry
Antibiotics, Antineoplastic - isolation & purification
Antibiotics, Antineoplastic - pharmacology
Benzophenones - chemistry
Benzophenones - isolation & purification
Biological and medical sciences
Fermentation
Medical sciences
Miscellaneous
Molecular Structure
Naphthacenes - chemistry
Naphthacenes - isolation & purification
Pharmacology. Drug treatments
Protein Kinase C - antagonists & inhibitors
Pyrones - chemistry
Pyrones - isolation & purification
Streptomyces
Structure-Activity Relationship
title Balmoralmycin, a New Angucyclinone, and Two Related Biosynthetic Shunt Products Containing a Novel Ring System
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