Sensitization of cocaine-stimulated increase in extracellular levels of corticotropin-releasing factor from the rat amygdala after repeated administration as determined by intracranial microdialysis

Using intracranial microdialysis, the effect of repeated cocaine (30 mg/kg i.p.) versus saline administration for 10 consecutive days upon basal and stimulated release of corticotropin-releasing factor (CRF) was examined in the central amygdaloid nucleus (CeA) of anesthetized rats. No significant di...

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Bibliographic Details
Published in:Neuroscience letters 1995-03, Vol.187 (3), p.169-172
Main Authors: Richter, Regina M., Pich, Emilio Merlo, Koob, George F., Weiss, Friedbert
Format: Article
Language:English
Subjects:
Aminopyridines - pharmacology
Amygdala
Amygdala - drug effects
Animals
Biological and medical sciences
Cocaine
Cocaine - pharmacology
Corticotropin-releasing factor
Corticotropin-Releasing Hormone - metabolism
Male
Medical sciences
Microdialysis
Neuropharmacology
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Rats, Wistar
Sensitization
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Summary:Using intracranial microdialysis, the effect of repeated cocaine (30 mg/kg i.p.) versus saline administration for 10 consecutive days upon basal and stimulated release of corticotropin-releasing factor (CRF) was examined in the central amygdaloid nucleus (CeA) of anesthetized rats. No significant differences in basal CRF levels between daily cocaine and saline treated groups were found. However, after cocaine challenge (10 mg/kg i.p.) the increase in CRF overflow was significantly greater in cocaine- as opposed to saline-pretreated rats (266 ± 55.4% versus 149 ± 8.5% of basal levels). Local administration of 4-aminopyridine produced a significant increase in CRF efflux (195 ± 58.5%) in daily cocaine-treated rats with only a weak response in the control group (127 ± 30.9%). These data demonstrate that repeated administration of cocaine enhances cocaine-induced release of CRF in the rat CeA. The sensitization of CRF release may play a significant role in psychostimulant-induced sensitization phenomena.
ISSN:0304-3940
1872-7972
DOI:10.1016/0304-3940(95)11365-4