Increased Brain Interstitial Fluid Adenosine Concentration During Hypoxia in Newborn Piglet

The effects of arterial hypoxia on interstitial fluid adenosine concentrations were studied in the frontal cortex and thalamus by the brain dialysis technique and in CSF from the cisterna magna of the newborn piglet. Acute hypoxia (PaO2 = 20 ± 1 mm Hg) increased the interstitial fluid adenosine conc...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 1987-04, Vol.7 (2), p.178-183
Main Authors: Park, T. S., Van Wylen, David G. L., Rubio, Rafael, Berne, Robert M.
Format: Article
Language:English
Subjects:
Adenosine - analysis
Animals
Animals, Newborn
Biological and medical sciences
Brain Chemistry
Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges
Cerebrovascular Circulation
Cisterna Magna - analysis
Extracellular Space - analysis
Fundamental and applied biological sciences. Psychology
Hydrogen - pharmacology
Hypoxanthine
Hypoxanthines - analysis
Hypoxia - metabolism
Inosine - analysis
Potassium - pharmacology
Regional Blood Flow - drug effects
Swine
Vertebrates: nervous system and sense organs
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Summary:The effects of arterial hypoxia on interstitial fluid adenosine concentrations were studied in the frontal cortex and thalamus by the brain dialysis technique and in CSF from the cisterna magna of the newborn piglet. Acute hypoxia (PaO2 = 20 ± 1 mm Hg) increased the interstitial fluid adenosine concentrations significantly from 0.68 ± 0.29 (SEM) to 1.60 ± 0.35 μM in the frontal cortex and from 1.03 ± 0.32 to 2.60 ± 0.86 μM in the thalamus (n = 8). Interstitial fluid inosine and hypoxanthine also increased significantly during hypoxia. In separate groups of piglets, the adenosine concentration in the cisterna magna CSF under normoxic conditions was 0.04 ± 0.01 μM (n = 5), which increased significantly to 0.17 ± 0.04 μM (n = 6) with hypoxia (PaO2 = 4.7 ± 1.2 mm Hg). Cisterna magna CSF inosine levels did not change significantly during the severe hypoxia. Adenosine concentrations found in the interstitial space and CSF of newborn piglets under normoxic and hypoxic conditions are within the vasodilator range. These results thus suggest that in the neonatal brain adenosine may play a role in regulating blood flow during hypoxia.
ISSN:0271-678X
1559-7016
DOI:10.1038/jcbfm.1987.41