Mycobacterium paratuberculosis Infection in a Colony of Stumptail Macaques (Macaca arctoides)

Mycobacterium paratuberculosis infection was documented in a colony of stumptail macaque monkeys (Macaca arctoides), with 29 (76%) of 38 monkeys infected and shedding organisms in feces. Thirteen deaths have occurred during the past five years. Animals without overt clinical disease were shedding as...

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Bibliographic Details
Published in:The Journal of infectious diseases 1987-05, Vol.155 (5), p.1011-1019
Main Authors: McClure, Harold M., Chiodini, Rodrick J., Anderson, Daniel C., Swenson, R. Brent, Thayer, Walter R., Coutu, Jessica A.
Format: Article
Language:English
Subjects:
Animal bacterial diseases
Animal diseases
Animals
Antibodies
Antibodies, Bacterial - analysis
Bacterial diseases
Biological and medical sciences
Colon - microbiology
Colon - pathology
Crohn disease
Enteritis - pathology
Feces
Feces - microbiology
Female
Infections
Infectious diseases
Intestinal Mucosa - pathology
Intestine, Small - microbiology
Intestine, Small - pathology
Liver - pathology
Lymph nodes
Lymph Nodes - pathology
Macaca
Medical sciences
Monkey Diseases - epidemiology
Monkey Diseases - immunology
Monkey Diseases - microbiology
Monkey Diseases - pathology
Mycobacterium - growth & development
Mycobacterium - immunology
Mycobacterium - isolation & purification
Mycobacterium paratuberculosis
Original Articles
Paratuberculosis
Paratuberculosis - epidemiology
Paratuberculosis - immunology
Paratuberculosis - microbiology
Paratuberculosis - pathology
Primates
Tuberculosis
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Summary:Mycobacterium paratuberculosis infection was documented in a colony of stumptail macaque monkeys (Macaca arctoides), with 29 (76%) of 38 monkeys infected and shedding organisms in feces. Thirteen deaths have occurred during the past five years. Animals without overt clinical disease were shedding as many as 2 × 106 colony-forming units of M. paratuberculosis/g of feces. Intestinal tissues from animals dying of this disease contained up to 108 colony-forming units of M. paratuberculosis/g of tissue. The clinical and pathological features of paratuberculosis in this species were comparable to those reported for paratuberculosis in ruminants and Mycobacterium avium infections in primates. By enzyme-linked immunosorbent assay, antibodies to M. paratuberculosis were found in 79%–84% of the animals. Antibodies could not be detected in six animals with clinical disease. These findings extend the natural host range of M. paratuberculosis to include nonhuman primates and add support to current suggestions that M. paratuberculosis may be pathogenic for humans.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/155.5.1011