The electrophysiological effects of multiple subpial transection (MST) in an experimental model of epilepsy induced by cortical stimulation

Multiple subpial transection (MST) is an effective surgical therapy for patients with intractable seizures whose epileptogenic lesions lie in the cortex and are unresectable. Morrell developed this procedure and reported clinical results obtained using it. However, only the disappearance of epilepti...

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Bibliographic Details
Published in:Epilepsy research 1995-05, Vol.21 (1), p.1-9
Main Authors: Sugiyama, Shuichi, Fujii, Masami, Ito, Haruhide
Format: Article
Language:English
Subjects:
After-discharge
Animals
Biological and medical sciences
Cerebral Cortex - pathology
Cerebral Cortex - physiopathology
Cerebral Cortex - surgery
Cortical stimulation
Electric Stimulation
Electroencephalography
Electrophysiology
Epilepsy - pathology
Epilepsy - physiopathology
Epilepsy - surgery
Female
Frontal Lobe - pathology
Frontal Lobe - physiopathology
Frontal Lobe - surgery
Interneuronal conduction
Interneurons - pathology
Interneurons - physiology
Kindling, Neurologic - physiology
Male
Medical sciences
Multiple subpial transection
Neural Conduction - physiology
Neurosurgery
Parietal Lobe - pathology
Parietal Lobe - physiopathology
Parietal Lobe - surgery
Rabbits
Skull, brain, vascular surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
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Summary:Multiple subpial transection (MST) is an effective surgical therapy for patients with intractable seizures whose epileptogenic lesions lie in the cortex and are unresectable. Morrell developed this procedure and reported clinical results obtained using it. However, only the disappearance of epileptiform discharges after MST in an experimental model of epilepsy has been demonstrated. The aim of this study was to establish the histological changes caused by MST and evaluate the effects of this procedure on interneuronal discharge spread in an epilepsy model, i.e. acute cortical kindling in rabbits. Histologically, vertical cracks in the transected cortex with mild gliosis and very little tissue disruption were observed. Horizontal fibers across the crack had been transected, whereas vertical fibers and neuronal cell bodies were preserved. The stimulation-induced after-discharges (ADO were analyzed: cortical hyperactivity across the transected zone was reduced significantly earlier than that in the control group. Propagation of ADs induced by the kindling effect was also inhibited. These results suggest that MST interrupts not only neuronal synchronization, but also excitatory interneuronal conduction, in this epilepsy model.
ISSN:0920-1211
1872-6844
DOI:10.1016/0920-1211(95)00003-S