Changes in mouse brain neurotensin receptor density following chronic infusion of neurotensin

Many centrally acting drugs affect neurotensin (NT) systems by increasing levels of the peptide in specific brain regions. If these changes represent increases in extracellular NT levels, then changes in NT receptors would be expected. The focus of this study was to examine the effects of continous...

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Bibliographic Details
Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1995, Vol.16 (3), p.501-504
Main Authors: Campbell, Andrew D., Erwin, V.Gene
Format: Article
Language:English
Subjects:
Agonist
Animals
Brain
Brain - drug effects
Brain - metabolism
Chronic neurotensin administration
High-affinity neurotensin receptor
Infusion Pumps, Implantable
Levocabastine
Low-affinity neurotensin receptor
Male
Mice
Mice, Inbred Strains
Neuropeptide
Neurotensin
Neurotensin - pharmacology
Osmotic pump
Receptor regulation
Receptors, Neurotensin - drug effects
Receptors, Neurotensin - metabolism
Time Factors
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Summary:Many centrally acting drugs affect neurotensin (NT) systems by increasing levels of the peptide in specific brain regions. If these changes represent increases in extracellular NT levels, then changes in NT receptors would be expected. The focus of this study was to examine the effects of continous exposure of NT receptors to agonist. Continous infusion of NT (0.6 or 6 nmol/h) into the lateral ventricle via an osmotic minipump for 3 days caused a significant increase (over saline infusion) in total and low-affinity NT receptor density in the cerebellum of LS mice. High-affinity NT receptor density was increased in the frontal cortex. Seven days of NT infusion (6 nmol/h) caused no changes in NT receptor density.
ISSN:0196-9781
1873-5169
DOI:10.1016/0196-9781(94)00220-Z