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Colonization of Gnotobiotic Piglets with Campylobacter pyloridis—An Animal Model?
The strong association between the presence of Campylobacter polyridis in human gastric mucosa and histological gastritis suggests an etiologic role for these organisms in nonulcer dyspepsia and perhaps in peptic ulcer. Whether C. pyloridis is a pathogen or merely a commensal of a previously altered...
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Published in: | The Journal of infectious diseases 1987-06, Vol.155 (6), p.1344-1344 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
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Summary: | The strong association between the presence of Campylobacter polyridis in human gastric mucosa and histological gastritis suggests an etiologic role for these organisms in nonulcer dyspepsia and perhaps in peptic ulcer. Whether C. pyloridis is a pathogen or merely a commensal of a previously altered mucosa has yet to be established. Independent studies by two human volunteers suggest a pathogenic role. The authors feel that experimental infection of humans should be discouraged, especially because C. pyloridis is present in 63% of patients who have carcinoma of the stomach. They report here the successful infection of gnotobiotic piglets with C. pyloridis . A litter of ten piglets delivered by cesarean section were transferred to germ-free isolators, where they were maintained for the duration of the experiment. |
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ISSN: | 0022-1899 1537-6613 |
DOI: | 10.1093/infdis/155.6.1344 |