The Need for Ventilatory Support During Bystander CPR

Study objective: To compare CPR with chest compressions plus ventilatory support (CC+V) and chest compressions alone (CC). Design: Prospective, randomized study. Setting: Research laboratory. Interventions: After 2 minutes of ventricular fibrillation, 18 domestic swine (20 to 35 kg) were treated fir...

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Bibliographic Details
Published in:Annals of emergency medicine 1995-09, Vol.26 (3), p.342-350
Main Authors: Berg, Robert A, Wilcoxson, David, Hilwig, Ronald W, Kern, Karl B, Sanders, Arthur B, Otto, Charles W, Eklund, Diane K, Ewy, Gordon A
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Biological and medical sciences
Cardiopulmonary Resuscitation - methods
Disease Models, Animal
Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care
Emergency Medical Services
Heart Massage - methods
Hemodynamics
Intensive care medicine
Medical sciences
Oxygen - blood
Random Allocation
Survival Analysis
Swine
Time Factors
Treatment Outcome
Ventricular Fibrillation - blood
Ventricular Fibrillation - physiopathology
Ventricular Fibrillation - therapy
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Summary:Study objective: To compare CPR with chest compressions plus ventilatory support (CC+V) and chest compressions alone (CC). Design: Prospective, randomized study. Setting: Research laboratory. Interventions: After 2 minutes of ventricular fibrillation, 18 domestic swine (20 to 35 kg) were treated first with CC or CC+V for 10 minutes, then with standard advanced cardiac life support. Results: Hemodynamics, survival, and neurologic outcome were determined. All 8 swine subjected to CC+V and all 10 subjected to CC showed return of spontaneous circulation. One animal in each group died within 1 hour. Seven of 8 animals in the CC+V group survived for 24 and 48 hours, compared with 9 of 10 CC animals at 24 hours and 8 of 10 at 48 hours. All 48-hour survivors were neurologically normal. Conclusion: In this experimental model of bystander CPR, we could not detect a difference in hemodynamics, 48-hour survival, or neurologic outcome when CPR was applied with and without ventilatory support. [Berg RA, Wilcoxson D, Hilwig RW, Kern KB, Sanders AB, Otto CW, Eklund DK, Ewy GA: The need for ventilatory support during bystander CPR. Ann Emerg Med September 1995;26:342-350.]
ISSN:0196-0644
1097-6760
DOI:10.1016/S0196-0644(95)70084-6