Visualisation of changes in regional cerebral blood flow (rCBF) produced by ketamine using long TE gradient-echo sequences: Preliminary results

Autoradiographic studies have shown that low dose ketamine produces increases in regional glucose utilisation and blood flow in the hippocampus, cerebral cortex, and olfactory lobe in the rat brain, probably due to antagonism at the NMDA receptor. Functional MRI using deoxyhaemoglobin contrast can b...

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Bibliographic Details
Published in:Magnetic resonance imaging 1995, Vol.13 (4), p.549-553
Main Authors: Burdett, N.G., Menon, D.K., Carpenter, T.A., Jones, J.G., Hall, L.D.
Format: Article
Language:English
Subjects:
Anesthetics, Dissociative - pharmacology
Anesthetics, Inhalation - pharmacology
Animals
Biological and medical sciences
Cardiovascular system
Cerebrovascular Circulation - drug effects
Excitatory Amino Acid Antagonists - pharmacology
Functional imaging
Halothane - pharmacology
Infusions, Intravenous
Investigative techniques, diagnostic techniques (general aspects)
Ketamine - pharmacology
Magnetic Resonance Imaging
Medical sciences
MRI
N-methyl- d-aspartate (NMDA) antagonists
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Rats
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
Regional cerebral blood flow (rCBF)
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Summary:Autoradiographic studies have shown that low dose ketamine produces increases in regional glucose utilisation and blood flow in the hippocampus, cerebral cortex, and olfactory lobe in the rat brain, probably due to antagonism at the NMDA receptor. Functional MRI using deoxyhaemoglobin contrast can be used to study changes in regional cerebral blood flow (rCBF). Long TE gradient-echo sequences were used to study changes in rCBF produced by low dose ketamine in rats anaesthetised with nitrous oxide, supplemented with either halothane (HAL) or fentanyl/fluanisone/midazolam (FFM) combination. Images from rats in the FFM group showed a 10–14% increase in signal intensity in the hippocampus, cerebral cortex, and olfactory lobe following either a single bolus or a low dose infusion of ketamine ( p < .05). These changes were significantly reduced in the HAL group ( p < .005). Halothane is known to attenuate the changes in regional glucose utilisation produced by the noncompetitive NMDA antagonist dizocilpine (MK-801), and its effects on ketamine-induced changes in rCBF seen in this study may be due to a similar effect. The potential use of functional MRI in studying the effect of pharmacological interventions on rCBF is discussed.
ISSN:0730-725X
1873-5894
DOI:10.1016/0730-725X(95)00010-E