Mating patterns in malaria parasite populations of Papua New Guinea

Description of the genetic structure of malaria parasite populations is central to an understanding of the spread of multiple-locus drug and vaccine resistance. The Plasmodium falciparum mating patterns from Madang, Papua New Guinea, where intense transmission of malaria occurs, are described here....

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1995-09, Vol.269 (5231), p.1709-1711
Main Authors: Paul, R.E.L. (University of Oxford, Oxford, UK.), Packer, M.J, Walmsley, M, Lagog, M, Ranford-Cartwright, L.C, Paru, R, Day, K.P
Format: Article
Language:English
Subjects:
Alleles
Animal reproduction
Animals
Anopheles - parasitology
Antimalarials - pharmacology
Base Sequence
Biological and medical sciences
Drug resistance
Drug Resistance - genetics
Drug resistance in microorganisms
Female
Fundamental and applied biological sciences. Psychology
GENE
GENES
Genes, Protozoan
Genetic loci
Genetic Variation
Genetics
Genetics of eukaryotes. Biological and molecular evolution
Genotype
Genotypes
Health aspects
Heterozygote
HOMOCIGOTOS
HOMOZYGOTE
Humans
Inbreeding
Insect Vectors - parasitology
Laboratory Experiments
Linkage Disequilibrium
Malaria
Malaria, Falciparum - parasitology
Malaria, Falciparum - transmission
Male
Merozoite Surface Protein 1
Microbial drug resistance
Molecular Sequence Data
Mosquitos
Oocysts
PAPOUASIE NOUVELLE GUINEE
Papua New Guinea
PAPUA NUEVA GUINEA
Parasite hosts
Parasites
PLASMODIUM FALCIPARUM
Plasmodium falciparum - drug effects
Plasmodium falciparum - genetics
Plasmodium falciparum - physiology
POLIMORFISMO GENETICO
POLYMORPHISME GENETIQUE
Population genetics
Population genetics, reproduction patterns
Protein Precursors - genetics
Protozoa
Protozoan Proteins - genetics
Reproduction
Sampling
Sexual behavior
Statistical Distributions
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Summary:Description of the genetic structure of malaria parasite populations is central to an understanding of the spread of multiple-locus drug and vaccine resistance. The Plasmodium falciparum mating patterns from Madang, Papua New Guinea, where intense transmission of malaria occurs, are described here. A high degree of inbreeding occurs in the absence of detectable linkage disequilibrium. This contrasts with other studies, indicating that the genetic structure of malaria parasite populations is neither clonal nor panmictic but will vary according to the transmission characteristics of the region
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7569897