Interleukin-5 production by T lymphocytes in atheroembolic disease with hypereosinophilia

Atheroembolic disease is a consequence of widespread cholesterol microembolization, most often caused by catheterization of a severely atherosclerotic aorta. A transient hypereosinophilia has been reported in up to 80% of the patients; thus, eosinophilia is considered an important clue to the diagno...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 1995-09, Vol.96 (3), p.427-429
Main Authors: Cogan, Elie, Schandené, Liliane, Papadopoulos, Théodore, Crusiaux, Alain, Goldman, Michel
Format: Article
Language:English
Subjects:
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cells, Cultured
Embolism, Cholesterol - blood
Embolism, Cholesterol - complications
Embolism, Cholesterol - metabolism
Eosinophilia - complications
Female
Humans
Interleukin-5 - biosynthesis
Interleukin-5 - blood
Medical sciences
Middle Aged
Monocytes - metabolism
T-Lymphocytes - metabolism
Time Factors
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Summary:Atheroembolic disease is a consequence of widespread cholesterol microembolization, most often caused by catheterization of a severely atherosclerotic aorta. A transient hypereosinophilia has been reported in up to 80% of the patients; thus, eosinophilia is considered an important clue to the diagnosis of this disorder. Interleukin (IL)-5 is a cytokine secreted by CD4 super(+) T cells, mast cells, and eosinophils, which promotes the differentiation and activation of eosinophils. Indeed, increased production of IL-5 has been demonstrated in several diseases associated with eosinophilia. In this report we provide evidence that hypereosinophilia associated with atheroembolic disease is related to IL-5 release by activated T cells.
ISSN:0091-6749
1097-6825
DOI:10.1016/S0091-6749(95)70065-X