Relationship between erythrocyte magnesium, plasma electrolytes and cortisol, and intensity of symptoms in major depressed patients

53 male and female drug-free major depressed patients were separated into three groups according to the severity of the depression. In the entire regrouped population, plasma and erythrocyte magnesium (Mg) were shown to increase as compared with 48 healthy controls, confirming our previous studies....

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Bibliographic Details
Published in:Journal of affective disorders 1995-06, Vol.34 (3), p.201-209
Main Authors: Widmer, Jean, Henrotte, Jean-Georges, Raffin, Yvette, Bovier, Philippe, Hilleret, Henriette, Gaillard, Jean-Michel
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Affective disorder
Biological and medical sciences
Bipolar Disorder - blood
Bipolar Disorder - diagnosis
Bipolar Disorder - psychology
Calcium
Calcium - blood
Cortisol
Depression
Depressive Disorder - blood
Depressive Disorder - diagnosis
Depressive Disorder - psychology
Electrolyte
Electrolytes - blood
Erythrocyte
Erythrocytes - metabolism
Female
Humans
Hydrocortisone - blood
Magnesium
Magnesium - blood
Male
Medical sciences
Middle Aged
Mood disorders
Potassium
Psychology. Psychoanalysis. Psychiatry
Psychomotor Performance - physiology
Psychopathology. Psychiatry
Reference Values
Sex Factors
Sodium
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Summary:53 male and female drug-free major depressed patients were separated into three groups according to the severity of the depression. In the entire regrouped population, plasma and erythrocyte magnesium (Mg) were shown to increase as compared with 48 healthy controls, confirming our previous studies. The middle and highly depressed patients had higher erythrocyte and also plasma Mg levels than either lowly depressed patients or controls. Only, a few differences were noticed in plasma sodium, potassium and calcium (Ca) in the three groups of patients, except for ultrafiltrable plasma Ca, measured for the first time in affective disorders. Thus, erythrocyte and also plasma Mg are shown to be associated with the intensity of the depression. As blood hypomagnaesemia is often related to hyperexcitabiltiy, further investigations are actually in process to shown whether hypermagnesaemia might be, in contrast, associated with psychomotor retardation as observed in many depressed patients.
ISSN:0165-0327
1573-2517
DOI:10.1016/0165-0327(95)00018-I