A study of genetic linkage in schizophrenia

Families with more than one member affected by schizophrenia were identified and their members were interviewed. Four standardized diagnostic definitions (PSE, DSM-III, ICD-9, Feighner) were applied to all subjects who were classified as schizophrenic or not schizophrenic according to each definitio...

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Bibliographic Details
Published in:Psychological medicine 1987-05, Vol.17 (2), p.363-370
Main Authors: Andrew, B., Watt, D. C., Gillespie, C., Chapel, H.
Format: Article
Language:English
Subjects:
Genetic Linkage
Genetic Markers
HLA Antigens - genetics
Humans
Pedigree
Risk
Schizophrenia - genetics
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Summary:Families with more than one member affected by schizophrenia were identified and their members were interviewed. Four standardized diagnostic definitions (PSE, DSM-III, ICD-9, Feighner) were applied to all subjects who were classified as schizophrenic or not schizophrenic according to each definition. Non-schizophrenic psychiatric disorders which have been shown to be familially associated with schizophrenia were also identified. Twenty blood markers were ascertained for all subjects and evidence of co-segregation with schizophrenia was sought. No selective segregation was found and therefore there was no evidence suggesting linkage or supporting a monogenic theory of transmission of susceptibility to schizophrenia.
ISSN:0033-2917
1469-8978
DOI:10.1017/S0033291700024910