CLINICAL AND PHARMACOKINETIC EVALUATIONS OF CEFUZONAM IN CHILDREN

A new parenteral cephalosporin antibiotic, cefuzonam (L-105, CZON), was evaluated for its safety, efficacy and pharmacokinetics in children. Twenty-two cases of bacterial infections including pneumonia, lung abscess, sepsis, urinary tract infection and soft tissue infections were treated with CZON....

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Bibliographic Details
Published in:Japanese journal of antibiotics 1987/03/25, Vol.40(3), pp.630-640
Main Authors: MEGURO, HIDENORI, ARIMASU, OSAMU, SHIRAISHI, HIROAKI, KOBAYASHI, MASAAKI, FUJII, RYOCHI, MASHIKO, JIN
Format: Article
Language:Japanese
Subjects:
Adolescent
Adult
Bacteria - drug effects
Bacterial Infections - drug therapy
Ceftizoxime - analogs & derivatives
Cephalosporins - metabolism
Cephalosporins - pharmacology
Cephalosporins - therapeutic use
Child
Child, Preschool
Drug Evaluation
Drug Resistance, Microbial
Female
Humans
Infant
Kinetics
Male
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Summary:A new parenteral cephalosporin antibiotic, cefuzonam (L-105, CZON), was evaluated for its safety, efficacy and pharmacokinetics in children. Twenty-two cases of bacterial infections including pneumonia, lung abscess, sepsis, urinary tract infection and soft tissue infections were treated with CZON. Clinical effective rate was 95%. Serum half-lives of CZON were 1.04-1.33 hours in children with normal renal and hepatic functions. Significant depressions of the normal fecal flora were observed and diarrhea or loose stool was encountered in 7 of the 22 treated cases (32%).
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.40.630