Pneumocystis carinii pneumonia in Zimbabwe

Summary Pneumocystis carinii pneumonia (PCP) is said to be rare in Africa, with reported rates of 0-22% in human- immunodeficiency-virus (HIV) infected individuals with respiratory symptoms. Over one year in a central hospital in southern Africa, 64 HIV-infected patients with acute diffuse pneumonia...

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Bibliographic Details
Published in:The Lancet (British edition) 1995-11, Vol.346 (8985), p.1258-1261
Main Authors: Malin, A.S, Gwanzura, L.K.Z, Robertson, V.J, Musvaire, P, Mason, P.R, Klein, S
Format: Article
Language:English
Subjects:
Adult
AIDS-Related Opportunistic Infections - blood
AIDS-Related Opportunistic Infections - diagnosis
AIDS-Related Opportunistic Infections - diagnostic imaging
AIDS/HIV
Algorithms
Alveoli
Bacilli
Bronchoalveolar Lavage Fluid - microbiology
Bronchoscopy
Bronchus
CD4 antigen
CD4 Lymphocyte Count
Diagnosis, Differential
Female
Fiber Optic Technology
Forecasting
Fungi
HIV
Human immunodeficiency virus
Humans
Kaposi's sarcoma
Logistic Models
Lung Neoplasms - diagnosis
Lymphocytes
Lymphocytes T
Male
Middle Aged
Oxygen - blood
Patients
Penicillin
Penicillins - therapeutic use
Pneumocystis carinii
Pneumonia
Pneumonia, Pneumocystis - blood
Pneumonia, Pneumocystis - diagnosis
Pneumonia, Pneumocystis - diagnostic imaging
Population
Radiographs
Radiography
Regression models
Resource management
Respiration
Respiratory rate
Sarcoma
Sarcoma, Kaposi - diagnosis
Signs and symptoms
Smear
Sputum
Sputum - microbiology
Tuberculosis
Tuberculosis, Pulmonary - blood
Tuberculosis, Pulmonary - diagnosis
Tuberculosis, Pulmonary - diagnostic imaging
Viruses
Zimbabwe
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Summary:Summary Pneumocystis carinii pneumonia (PCP) is said to be rare in Africa, with reported rates of 0-22% in human- immunodeficiency-virus (HIV) infected individuals with respiratory symptoms. Over one year in a central hospital in southern Africa, 64 HIV-infected patients with acute diffuse pneumonia unresponsive to penicillin and sputum smear-negative for acid-fast bacilli underwent fibreoptic bronchoscopy. Bronchoalveolar lavage fluid was assessed for bacteria, fungi, Pneumocystis carinii, and mycobacteria. 21 patients (33%) had PCP and 24 (39%) had tuberculosis; 6 of these had both infections. 5 patients had Kaposi's sarcoma (KS) associated with PCP, tuberculosis, or another infection, in 1 patient KS was the only finding, and in 21 no pathogen was identified. A logistic regression model was used to assess clinical, radiographic, and arterial blood gas predictors of PCP and tuberculosis. Fine reticulonodular shadowing on the chest radiograph (nodular component
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(95)91862-0