Angiotensin-converting enzyme gene polymorphism in Japanese patients with hypertrophic cardiomyopathy

To examine the contribution of the angiotensin-converting enzyme (ACE) gene to hypertrophic cardiomyopathy (HCM), we determined the ACE insertion/deletion ( I D ) polymorphism in 80 patients with HCM and 88 of their unaffected siblings and children. Patients were divided into familial or solitary HC...

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Bibliographic Details
Published in:The American heart journal 1995-11, Vol.130 (5), p.1089-1093
Main Authors: Yoneya, Keiji, Okamoto, Hiroshi, Machida, Masaharu, Onozuka, Hisao, Noguchi, Munechika, Mikami, Taisei, Kawaguchi, Hideaki, Murakami, Masaaki, Uede, Toshimitsu, Kitabatake, Akira
Format: Article
Language:English
Subjects:
Aged
Base Sequence
Biological and medical sciences
Cardiology. Vascular system
Cardiomyopathy, Hypertrophic - ethnology
Cardiomyopathy, Hypertrophic - genetics
Female
Genes, ras
Genotype
Heart
Humans
Japan
Male
Medical sciences
Middle Aged
Molecular Sequence Data
Myocarditis. Cardiomyopathies
Peptidyl-Dipeptidase A - genetics
Polymorphism, Genetic
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Summary:To examine the contribution of the angiotensin-converting enzyme (ACE) gene to hypertrophic cardiomyopathy (HCM), we determined the ACE insertion/deletion ( I D ) polymorphism in 80 patients with HCM and 88 of their unaffected siblings and children. Patients were divided into familial or solitary HCM (FHCM or SHCM) groups with or without affected family members. Genotypes were identified by the polymerase chain reaction (PCR) with oligonucleotide primers flanking the polymorphic region in intron 16 of the ACE gene to amplify template DNA prepared from peripheral leukocytes. D-allele frequencies were 0.38 in all subjects, 0.42 in patients with HCM, and 0.35 in relatives ( p < 0.05). The probability ratios were 1.98, 1.46, and 2.97 in patients with HCM, FHCM, and SHCM, respectively. The D allele frequency was higher in SHCM than in FHCM ( p < 0.05). The findings suggest that HCM, especially in solitary cases, is partially determined by genetic disposition. Findings imply that the ACE D allele is one of the genetic contributing factors associated with cardiac hypertrophy in HCM.
ISSN:0002-8703
1097-6744
DOI:10.1016/0002-8703(95)90213-9