Interventions based on the possibility that oxidative stress contributes to sarcopenia

Skeletal muscle is a tissue which accounts for a large part of the body's total oxygen consumption at rest, due to its large mass and the majority of oxygen consumption during vigorous physical activity. Also, skeletal muscle and nervous tissues do not possess the very high repair capacities th...

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Bibliographic Details
Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 1995-11, Vol.50 Spec No (Special), p.157-161
Main Author: Weindruch, R
Format: Article
Language:English
Subjects:
Aging
Aging - metabolism
Aging - physiology
Animals
Animals, Genetically Modified
Antioxidants - therapeutic use
Body Composition
Disease Models, Animal
Energy Intake
Free Radicals - metabolism
Health care
Humans
Muscle Fibers, Skeletal - metabolism
Muscle Fibers, Skeletal - physiology
Muscle, Skeletal - innervation
Muscle, Skeletal - metabolism
Muscle, Skeletal - physiopathology
Muscular Atrophy - metabolism
Muscular Atrophy - physiopathology
Muscular system
Neurons - metabolism
Neurons - physiology
Oxidation
Oxidative Stress
Oxygen Consumption - physiology
Physical Exertion - physiology
Skeletal system
Space life sciences
Stress, Physiological - metabolism
Stress, Physiological - physiopathology
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Summary:Skeletal muscle is a tissue which accounts for a large part of the body's total oxygen consumption at rest, due to its large mass and the majority of oxygen consumption during vigorous physical activity. Also, skeletal muscle and nervous tissues do not possess the very high repair capacities that occur in more mitotically active tissues. Accordingly, oxidative stress may accumulate with age in these tissues and contribute to the development of sarcopenia; however, this possibility has not been thoroughly investigated. Although long-term intervention studies which test the hypothesis that oxidative stress contributes to sarcopenia have not been conducted, recent findings using the caloric restriction (CR) paradigm for studying retarded aging processes indirectly support this concept. Several research directions appear important to pursue, including the measurement of free radical production in skeletal muscle at diverse ages, antioxidant supplementation as an intervention for retarding the development of sarcopenia, the use of genetically manipulated animal models, and determining the influence of CR on oxidative stress in specific skeletal muscles and individual fibers and neurons therein.
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/50A.Special_Issue.157