Superoxide dismutase and lipid-bound sialic acid in sera from children with cancers and juvenile chronic arthritis

Both experimental and epidemiological studies suggest that patients with autoimmune and other chronic inflammatory diseases are more prone to develop cancer. The aim of the present investigation is to find some typical differences between the content of lipid-bound sialic acid (LSA) and the activity...

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Bibliographic Details
Published in:European journal of cancer prevention 1995-10, Vol.4 (5), p.429-435
Main Authors: Maneva, A, Michailova, D, Sarbenova, M, Christozova, I, Taleva, B
Format: Article
Language:English
Subjects:
Adolescent
Arthritis, Juvenile - blood
Arthritis, Juvenile - pathology
Autoimmune Diseases - blood
Autoimmune Diseases - pathology
Biomarkers - blood
Biomarkers, Tumor - blood
Cell Transformation, Neoplastic - pathology
Child
Child, Preschool
Hodgkin Disease - blood
Humans
Infant
Lymphoma, Non-Hodgkin - blood
N-Acetylneuraminic Acid
Neoplasms - blood
Neoplasms - etiology
Neoplasms - pathology
Neuroblastoma - blood
Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood
RESEARCH PAPERS
Risk Factors
Sensitivity and Specificity
Sialic Acids - blood
Superoxide Dismutase - blood
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Summary:Both experimental and epidemiological studies suggest that patients with autoimmune and other chronic inflammatory diseases are more prone to develop cancer. The aim of the present investigation is to find some typical differences between the content of lipid-bound sialic acid (LSA) and the activity of Superoxide dismutase (SOD) in sera from children with neoplastic diseases and juvenile chronic arthritis (JCA). Our results show 30% lower SOD activity in the sera from children with cancer compared with the sera from children with JCA. LSA levels 102% and 166% higher than in children with JCA were observed in the sera from children with blood and solid cancers, respectively. The relation LSA/SOD is about fivefold higher in children with cancers. A negative correlation (r = 0.720, P < 0.001) exists between LSA and SOD in sera from children with cancers. No such correlation was established in the group of children with JCA. We suppose that such differentiation disappears in the beginning of neoplastic process during prolonged therapy of autoimmune diseases. From our findings SOD and LSA appear to be putative markers of malignant disease with potential usefulness not only in JCA but also in other conditions associated with an increased risk of neoplastic development.
ISSN:0959-8278
1473-5709
DOI:10.1097/00008469-199510000-00012