Partial sleep deprivation reduces natural killer cell activity in humans

Sleep disturbance, measured by either subjective report or electroencephalographic (EEG) assessment of sleep, correlates with a reduction of natural killer (NK) cell activity in major depression. To test whether sleep loss independent of mood disturbance alters daytime values of cellular immune func...

Full description

Saved in:
Bibliographic Details
Published in:Psychosomatic medicine 1994-11, Vol.56 (6), p.493-498
Main Authors: Irwin, M, Mascovich, A, Gillin, J C, Willoughby, R, Pike, J, Smith, T L
Format: Article
Language:English
Subjects:
Adult
Electroencephalography
Humans
Immunity, Cellular - immunology
Immunity, Cellular - physiology
Killer Cells, Natural - immunology
Killer Cells, Natural - physiology
Lymphocytes - immunology
Male
Middle Aged
Polysomnography
Sleep Deprivation
Sleep Stages
Sleep, REM
Stress, Psychological - psychology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sleep disturbance, measured by either subjective report or electroencephalographic (EEG) assessment of sleep, correlates with a reduction of natural killer (NK) cell activity in major depression. To test whether sleep loss independent of mood disturbance alters daytime values of cellular immune function, the effect of late-night partial sleep deprivation on NK cell activity was studied in 23 medically and psychiatrically healthy male volunteers. After a night of sleep deprivation between 3 and 7 AM, NK cell activity was reduced in 18 of the 23 subjects with average lytic activity reduced significantly (p < .01) to a level 72% of the mean of three separate baseline values. After a night of resumed nocturnal sleep, NK cell activity had returned to baseline levels. These data implicate sleep in the modulation of natural immunity and demonstrate that even modest disturbances of sleep produce a reduction of NK cell activity.
ISSN:0033-3174
DOI:10.1097/00006842-199411000-00004