Cloning of a bradyzoite-specific gene of Toxoplasma gondii encoding a cytoplasmic antigen

The tissue-cyst stage of the protozoan pathogen Toxoplasma gondii has been shown to play a critical role in the transmission of the parasite, maintenance of the latent infection and in reactivation of disease in intermediate hosts. The transmission of T. gondii infection to humans commonly occurs fr...

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Bibliographic Details
Published in:Molecular and biochemical parasitology 1995-07, Vol.73 (1), p.253-257
Main Authors: Parmley, Stephen F., Weiss, Louis M., Yang, Shumin
Format: Article
Language:English
Subjects:
Amino Acid Sequence
amino acid sequences
Animals
antigens
Antigens, Protozoan - genetics
bag5 gene
Base Sequence
Bradyzoite
bradyzoites
cDNA cloning
cloning
Cloning, Molecular
complementary DNA
Cyst
Cytoplasm - immunology
DNA Primers - genetics
DNA, Complementary - genetics
DNA, Protozoan - genetics
genbank/u23944
gene expression
Gene Expression Regulation, Developmental
Genes, Protozoan
heat shock proteins
Heat-shock protein
Molecular Sequence Data
nucleotide sequences
Polymerase Chain Reaction
structural genes
Toxoplasma - genetics
Toxoplasma - growth & development
Toxoplasma - immunology
Toxoplasma gondii
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Summary:The tissue-cyst stage of the protozoan pathogen Toxoplasma gondii has been shown to play a critical role in the transmission of the parasite, maintenance of the latent infection and in reactivation of disease in intermediate hosts. The transmission of T. gondii infection to humans commonly occurs from ingestion of raw or undercooked meat containing cysts from chronically infected animals, particularly pigs or sheep. Tissue cysts persist during the latent phase of infection for perhaps the entire life of the host. Reactivation of a previously latent infection resulting from cyst rupture in the brain is thought to be the major cause of toxoplasmic encephalitis in AIDS patients. Since tissue cysts are closely associated with disease and the persistence of T. gondii infection in the population, it is important to study the mechanisms of cyst growth, development and rupture. Tissue cysts develop when the invasive tachyzoite form differentiates to the slower growing bradyzoite form. Tachyzoites and bradyzoites exhibit morphological differences and express stage-specific antigens.
ISSN:0166-6851
1872-9428
DOI:10.1016/0166-6851(95)00100-F