Does nitric oxide play a role in liver function?

Nitric oxide (NO) is becoming increasingly recognised as a signalling molecule in many organs, although its role in the liver remains to be fully elucidated. There is no doubt that liver cells can produce NO in response to a variety of stimuli including Corynebacterium parvum-infection, lipopolysacc...

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Bibliographic Details
Published in:Cellular Signalling 1995-05, Vol.7 (4), p.313-318
Main Authors: Milbourne, Elizabeth A., Bygrave, Fyfe L.
Format: Article
Language:English
Subjects:
Animals
Corynebacterium Infections - enzymology
Digestive System Physiological Phenomena
hepatocytes
Kupffer cells
liver
Liver - cytology
Liver - physiology
Liver Diseases - enzymology
Liver Diseases - microbiology
Nitric oxide
Nitric Oxide - physiology
nitric oxide synthase
Nitric Oxide Synthase - biosynthesis
Signal Transduction
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Summary:Nitric oxide (NO) is becoming increasingly recognised as a signalling molecule in many organs, although its role in the liver remains to be fully elucidated. There is no doubt that liver cells can produce NO in response to a variety of stimuli including Corynebacterium parvum-infection, lipopolysaccharide (LPS) and a variety of cytokines. Within the liver, NO modulates some fundamental intracellular functions such as protein synthesis, mitochondrial electron transport and components of the citric acid cycle. Intercellular roles for NO in the liver may include drug metabolism and blood storage. Also, NO acts to protect the liver from immunological damage in models of hepatic inflammation. Understanding the role of NO in the liver may provide insight into the functioning of this organ in health and disease.
ISSN:0898-6568
1873-3913
DOI:10.1016/0898-6568(95)00005-A