Blockade of adenosine receptors during ischaemia increases systolic dysfunction but does not affect diastolic creep in stunned myocardium

• Published in: European heart journal 1994-12, Vol.15 (12), p.1705-1711
• Main Authors: RYNNING, S. E., HEXEBERG, E., BIRKELAND, S., WESTBY, J., GRONG, K.
• Format: Article
• Language: English
• Subjects: adenosine; Adenosine - physiology; Animals; Biological and medical sciences; Cardiology. Vascular system; Cats; Coronary heart disease; Diastolic creep; Heart; Heart - drug effects; Hemodynamics - drug effects; Male; Medical sciences; Myocardial Contraction - drug effects; Myocardial Contraction - physiology; Myocardial Stunning - physiopathology; Purinergic P1 Receptor Antagonists; stunning; systolic function; Theophylline - analogs & derivatives; Theophylline - pharmacology; Ventricular Dysfunction, Left - physiopathology
• ISSN: 0195-668X; 1522-9645
• DOI: 10.1093/oxfordjournals.eurheartj.a060455

The impact of adenosine receptor blockade on left ventricular systolic function and diastolic creep in stunned myocardium was studied in 20 sodium pentobarbital anaesthetized cats. A control group (n=10) was compared with a group (n=10) where adenosine receptors were blocked by 8-phenyltheophylline (7.5 mg. kg−1 i.v.) prior to a 10 min occlusion of the left anterior descending coronary artery. Regional function was assessed by sonomicrometry of the left ventricular anterior wall. Tissue blood flow and haemodynamic measurements were obtained at pre-occlusion, during occlusion, and after 30 and 60 min of reperfusion. Tissue blood flow in the LAD region was low and homogeneous during coronary occlusion in both groups. Systolic function assessed by regional shortening and inotropic parameters was significantly more reduced in the 8-PT treated group (P