Experimental candidiasis in liver injury

In an attempt to evaluate effects of liver injury and roles of iron metabolism on systemic fungal infection, experimental systemic Candida infection was produced in mice with galactosamine-induced liver injury. Survival rate and extent of fungal lesion are compared between mice with liver injury (Gr...

Full description

Saved in:
Bibliographic Details
Published in:Mycopathologia (1975) 1987-10, Vol.100 (1), p.37-42
Main Authors: ABE, F, NAGATA, S, HOTCHI, M
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Candida albicans
Candidiasis - etiology
Candidiasis - pathology
Experimental mycoses and models
Infectious diseases
Iron - metabolism
Liver - pathology
Liver Diseases - complications
Liver Diseases - pathology
Male
Medical sciences
Mice
Mice, Inbred ICR
Mycoses
Specific Pathogen-Free Organisms
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In an attempt to evaluate effects of liver injury and roles of iron metabolism on systemic fungal infection, experimental systemic Candida infection was produced in mice with galactosamine-induced liver injury. Survival rate and extent of fungal lesion are compared between mice with liver injury (Group 1) and ones without liver injury (Group 2). Median survival was 7 and 18 days in Group 1 and 2 respectively after 21 days observation. Mortality rate of Group 1 was significantly higher (P = 0.05) than that of Group 2. This difference was reflected to the extent of fungal lesions in that they were extensive and disseminated, involving the multiple organs in Group 1 but predominantly localized to the kidneys in Group 2. UIBC (unbound iron binding capacity) and TIBC (total iron binding capacity), i.e., serum transferrin as well as serum iron levels were significantly lower in Group 1 as compared with those in Group 2. These results indicate that hepatic injury promotes Candida infection in vivo and suggest that increased susceptibility to Candida in the presence of liver injury is, at least partially, attributable to low UIBC and/or TIBC.
ISSN:0301-486X
1573-0832
DOI:10.1007/BF00769566