Vascular muscle membrane cation mechanisms and total peripheral resistance

Passive and active carrier-mediated transport of sodium across vascular muscle membranes has been suggested to be more important in the increased total peripheral resistance found in genetic hypertension. Using manipulations of ion gradients and recordings of ion currents, membrane potentials, and t...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1987-11, Vol.10 (5 Pt 2), p.I20-I22
Main Author: Hermsmeyer, R K
Format: Article
Language:English
Subjects:
Animals
Biological Transport
Calcium - metabolism
Carrier Proteins - metabolism
Humans
Hypertension - metabolism
Hypertension - physiopathology
Ion Channels - metabolism
Membrane Potentials
Muscle, Smooth, Vascular - metabolism
Rats
Rats, Inbred SHR - metabolism
Sodium - metabolism
Sodium-Calcium Exchanger
Sodium-Potassium-Exchanging ATPase - metabolism
Vascular Resistance
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Summary:Passive and active carrier-mediated transport of sodium across vascular muscle membranes has been suggested to be more important in the increased total peripheral resistance found in genetic hypertension. Using manipulations of ion gradients and recordings of ion currents, membrane potentials, and tension, I have found evidence for calcium regulation as the central pathophysiological mechanism in spontaneously hypertensive rats. Increased sodium pump activity, which may be a partial compensation for the increased sodium influx in hypertension, may thus be secondary to altered calcium channel regulation in hypertension. The calcium channel, and the membrane potentials governing it, seem to be the most immediately important membrane mechanisms for hypertension research.
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.10.5_Pt_2.I20