Impact of the Human Immunodeficiency Virus Type-1 on Common Pediatric Illnesses in Zambia

Summary The seroprevalence of HIV-1 and in-patient mortality in children with common pediatric illnesses was studied. Between October 1990 and July 1991 at the Department of Paediatrics and Child Health, University Teaching Hospital (UTH), Lusaka, Zambia, mothers of all pediatric admissions were int...

Full description

Saved in:
Bibliographic Details
Published in:Journal of tropical pediatrics (1980) 1995-12, Vol.41 (6), p.348-353
Main Authors: Chintu, C., Luo, C., Bhat, G., DuPont, H. L., Mwansa-Salamu, P., Kabika, M., Zumla, A.
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - complications
Acquired Immunodeficiency Syndrome - mortality
Age Distribution
AIDS-Related Opportunistic Infections - mortality
AIDS/HIV
Biological and medical sciences
Child, Hospitalized - statistics & numerical data
Child, Preschool
Diarrhea - mortality
Diarrhea - virology
Failure to Thrive - mortality
Failure to Thrive - virology
Female
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infant
Malaria - mortality
Male
Medical sciences
Nutrition Disorders - mortality
Nutrition Disorders - virology
Pneumonia
Sex Distribution
Tropical medicine
Tuberculosis - mortality
Zambia - epidemiology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary The seroprevalence of HIV-1 and in-patient mortality in children with common pediatric illnesses was studied. Between October 1990 and July 1991 at the Department of Paediatrics and Child Health, University Teaching Hospital (UTH), Lusaka, Zambia, mothers of all pediatric admissions were interviewed and counselled for enrollment of their children into the study. Of a total of 1323 children seen, 1266 children (600 female and 666 male) were enrolled into the study. Pneumonia (28 per cent), malaria (24 per cent), malnutrition (18 per cent), and diarrhoea (10 per cent) constituted over 80 per cent of the total admission diagnoses. Tuberculosis (5 per cent) was the fifth commonest cause of admission (61 out of 1266 children). A total of 354 out of the 1266 (28 per cent) children were found to be seropositive for HIV-1 compared to a seroprevalence rate of 9 per cent in children attending accident and emergency for traumatic injuries (P=0.001). High HIV-1 seroprevalence rates were found in children with tuberculosis (69 per cent), malnutrition (41 per cent), pneumonia (28 per cent), and diarrhoea (24 per cent). The overall mortality in hospital among HIV-seropositive children (19 per cent) was significantly higher than those who were HIV-seronegative (9 per cent) (P= ≪0.0001).
ISSN:0142-6338
1465-3664
DOI:10.1093/tropej/41.6.348