Role of nitric oxide in cell-mediated tumor cytotoxicity

Strong and increasing evidence shows that nitric oxide (NO) contributes to immune function, and in particular to ‘non-specific host defense’. The aim of the present review was to focus the current understanding of the role of NO as a biochemical effector of l-arginine-dependent cell-mediated immune...

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Bibliographic Details
Published in:Advances in neuroimmunology 1995, Vol.5 (4), p.443-461
Main Authors: Cifone, M.Grazia, Cironi, Luisa, Meccia, M.Antonietta, Roncaioli, Paola, Festuccia, Claudio, De Nuntiis, Gasperina, D'Aló, Simona, Santoni, Angela
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Atmosphere
Biological Evolution
Brain - enzymology
cell-mediated tumor cytotoxicity
Cytotoxicity, Immunologic - physiology
Enzyme Induction
Hemocytes - physiology
Immune System - physiology
Invertebrates - enzymology
Invertebrates - immunology
Iron-Sulfur Proteins - metabolism
Isoenzymes - metabolism
Liver - enzymology
Mammals - immunology
Mammals - metabolism
Membrane Lipids - metabolism
Molecular Sequence Data
Nerve Tissue Proteins - metabolism
Nitric oxide
Nitric Oxide - physiology
Nitric Oxide Synthase - metabolism
Origin of Life
Phagocytosis - physiology
Rats
Snails - enzymology
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Summary:Strong and increasing evidence shows that nitric oxide (NO) contributes to immune function, and in particular to ‘non-specific host defense’. The aim of the present review was to focus the current understanding of the role of NO as a biochemical effector of l-arginine-dependent cell-mediated immune responses to neoplastic cells in vitro and in vivo. The cytokine-inducible nitric oxide synthase (NOS) seems to mainly be implicated in the cytotoxic activity of almost all the effector cells involved in tumor cell killing. The cytotoxic actions of NO against tumor cells appear to be related mainly to inhibition of several heme-containing enzymes of the mitochondrial electron transport complex and the citric acid cycle.
ISSN:0960-5428
DOI:10.1016/0960-5428(95)00028-3